2-METHYL-6-NITROPHENOL

Base Information

• Chemical Name: 2-METHYL-6-NITROPHENOL
• CAS No.: 13073-29-5
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.137
• Hs Code.: 2908999090
• Mol file: 13073-29-5.mol

Synonyms:o-Cresol,6-nitro- (7CI,8CI);2-Hydroxy-3-methylnitrobenzene;2-Hydroxy-3-nitrotoluol;2-Methyl-6-nitrophenol;6-Methyl-2-nitrophenol;6-Nitro-o-cresol;NSC 28585;

Chemical Property of 2-METHYL-6-NITROPHENOL

Chemical Property:

• Appearance/Colour: white like or light brown crystalline powder
• Vapor Pressure: 0.032mmHg at 25°C
• Melting Point: 70 °C
• Refractive Index: 1.596
• Boiling Point: 235.8 °C at 760 mmHg
• PKA: 7.48±0.24(Predicted)
• Flash Point: 104 °C
• PSA: 66.05000
• Density: 1.32g/cm³
• LogP: 2.13200

Purity/Quality:

99.5% ^*data from raw suppliers

2-Methyl-6-nitrophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-6-NITROPHENOL

There total 47 articles about 2-METHYL-6-NITROPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ortho-cresol (95-48-7,77504-84-8) → 2-methyl-6-nitrophenol (13073-29-5)

Guidance literature:

With copper(II) nitrate; toluene-4-sulfonic acid; In acetone; Reagent/catalyst; Reflux;

Reference yield: 97.0%

2-(2-methyl-6-nitrophenoxy)pyridine → 2-methyl-6-nitrophenol (13073-29-5)

Guidance literature:

2-(2-methyl-6-nitrophenoxy)pyridine; With methyl trifluoromethanesulfonate; In toluene; at 90 ℃; for 2h; Inert atmosphere;

With sodium; In methanol; toluene; at 80 ℃; for 0.5h; Inert atmosphere;

Reference yield: 92.0%

ortho-cresol (95-48-7,77504-84-8) → 2-methyl-4-nitrophenol (99-53-6) + 2-methyl-6-nitrophenol (13073-29-5)

Guidance literature:

With silica supported Al(NO₃)3*9H₂O; In acetone; at 20 ℃; for 0.333333h; regioselective reaction;

DOI:10.2174/1570178612666150108000402

upstream raw materials:

tri-ortho-cresyl phosphate

1-methyl-3-nitrobenzene

3-methylsalicylic acid

1-methyl-2,3-dinitrobenzene

Downstream raw materials:

2-amino-6-methylphenol

6-hydroxy-5-nitro-toluene-3-sulfonic acid

acetic acid-(2-methyl-6-nitro-phenyl ester)

toluene-4-sulfonic acid-(2-methyl-6-nitro-phenyl ester)

Refernces

• 1、 Bisarya,Joshi,Holkar. "Calcium nitrate - A new nitrating agent for nuclear nitration of substituted phenols". . p. 1125 - 1137. Retrieved 1993.
• 2、 Nojima,Isogami. "Studies on photochemical reactions of air pollutants. XIII. Formation of nitrophenols by the reactions of three toluene oxides with nitrogen dioxide in air". . p. 2426 - 2429. Retrieved 1994.
• 3、 -. "Synthesis method of 2-fluoro-3-nitrobenzoic acid intermediate raw material". Paragraph 0024-0027; 0038-0041; 0052-0055; 0066-0069; 0080. . Retrieved 2021/06/26.
• 4、 -. "A ortho-nitro phenol and its derivative synthesis method (by machine translation)". . . Retrieved 2017/08/23.