Ethyl 2-aminothiazole-5-carboxylate

Base Information

• Chemical Name: Ethyl 2-aminothiazole-5-carboxylate
• CAS No.: 32955-21-8
• Molecular Formula: C6H8N2O2S
• Molecular Weight: 172.208
• Hs Code.: 29339900
• Mol file: 32955-21-8.mol

Synonyms:2-Amino-5-(ethoxycarbonyl)thiazole;2-Aminothiazole-5-carboxylic acid ethyl ester;Ethyl 2-amino-1,3-thiazole-5-carboxylate;Ethyl 2-amino-5-thiazolecarboxylate;NSC 233051;Ethyl-2-aminothiazole-5-carboxylate;

Chemical Property of Ethyl 2-aminothiazole-5-carboxylate

Chemical Property:

• Vapor Pressure: 0.000701mmHg at 25°C
• Melting Point: 144-148 °C
• Refractive Index: 1.588
• Boiling Point: 308 °C at 760 mmHg
• PKA: 3.12±0.10(Predicted)
• Flash Point: 140.1 °C
• PSA: 93.45000
• Density: 1.336 g/cm³
• LogP: 1.48320
• Storage Temp.: 2-8°C
• Sensitive.: Moisture & Light Sensitive
• Water Solubility.: Insoluble in water

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-5-thiazolecarboxylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Amino-5-thiazolecarboxylic Acid Ethyl Ester is used in the synthesis of dual-action antidiabetic agents that inhibit glycogen phosphorylase.

Technology Process of Ethyl 2-aminothiazole-5-carboxylate

There total 12 articles about Ethyl 2-aminothiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

ethyl 3-ethoxyacrylate (1001-26-9) + urea (57-13-6) → 2-amino-thiazole-5-carboxylic acid ethyl ester (32955-21-8)

Guidance literature:

With potassium sulfide; copper; In tetrahydrofuran; water; at 55 ℃; for 1.5h; Temperature; Inert atmosphere;

Reference yield: 91.0%

ethyl 3-ethoxyacrylate (1001-26-9) → 2-amino-thiazole-5-carboxylic acid ethyl ester (32955-21-8)

Guidance literature:

ethyl 3-ethoxyacrylate; With N-Bromosuccinimide; In 1,4-dioxane; water;

With thiourea;

Reference yield: 90.0%

thiourea (17356-08-0) + 2-bromo-3-ethoxy-3-hydroxy-propionic acid ethyl ester → 2-amino-thiazole-5-carboxylic acid ethyl ester (32955-21-8)

Guidance literature:

In 1,4-dioxane; water; at 80 ℃; for 1h;

DOI:10.1016/S0040-4039(01)00161-7

upstream raw materials:

2-acetylamino-thiazole-5-carbonitrile

ethyl 2-chloro-3-oxopropanoate

thiourea

ethyl 2-<2-amino-5-(ethoxycarbonyl)-4-thiazolylthio>acetoacetate

Downstream raw materials:

ethyl 2-acetamidothiazole-5-carboxylate

2-(4-chloro-benzenesulfonylamino)-thiazole-5-carboxylic acid ethyl ester

2-aminothiazole-5-carboxylic acid

2-amino-thiazole-5-carboxylic acid hydrazide

Refernces

• 1、 -. "A kind of 3,4-dichloro-thiazole derivatives and process for their preparation and use". Paragraph 0036-0039; 0091-0092. . Retrieved 2016/10/08.
• 2、 -. "HETEROCYCLIC AMINO BERBAMINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF". Paragraph 0095; 0096. . Retrieved 2013/07/25.