3-(2-Hydroxyethyl)-2-oxazolidinone

Base Information

• Chemical Name: 3-(2-Hydroxyethyl)-2-oxazolidinone
• CAS No.: 3356-88-5
• Molecular Formula: C5H9NO3
• Molecular Weight: 131.131
• Hs Code.: 2934999090
• European Community (EC) Number: 468-930-3
• NSC Number: 57598
• UNII: C1Y9T3V4P4
• DSSTox Substance ID: DTXSID20187246
• Nikkaji Number: J42.645H
• Wikidata: Q27275073
• Mol file: 3356-88-5.mol

Synonyms:3356-88-5;3-(2-Hydroxyethyl)-2-oxazolidinone;3-(2-Hydroxyethyl)-1,3-oxazolidin-2-one;3-(2-Hydroxyethyl)oxazolidin-2-one;N-Hydroxyethyl-2-oxazolidone;2-Oxazolidinone, 3-(2-hydroxyethyl)-;NSC57598;3-(2'-Hydroxyethyl)-2-oxazolidone;NSC 57598;BRN 0115749;UNII-C1Y9T3V4P4;AI3-34576;C1Y9T3V4P4;N-(2-hydroxyethyl)oxazolidin-2-one;NSC-57598;EC 468-930-3;4-27-00-02523 (Beilstein Handbook Reference);WLN: T5NVOTJ A2Q;SCHEMBL20105;N-hydroxyethyl-2-oxazolidinone;DTXSID20187246;N-(2-hydroxyethyl)-2-oxazolidinone;MFCD00037351;STL301353;N-(2-hydroxyethyl)-oxazolidin-2-one;3-(2-hydroxy-ethyl)-2-oxazolidinone;3-(2-hydroxy-ethyl)oxazolidin-2-one;AKOS002942311;N-(2-hydroxyethyl)-oxazolidine-2-one;3-(2-hydroxy-ethyl)-oxazolidin-2-one;2-(2-Oxo-1,3-oxazolidin-3-yl)ethanol;TS-01709;3-(2-hydroxyethyl)1,3-oxazolidin-2-one;LS-100601;CS-0120019;FT-0613560;EC-000.1591;EN300-49814;3-(2-Hydroxyethyl)-1,3-oxazolidin-2-one #;W16065;3-(2-hydroxyethyl)-2-oxazolidinone, AldrichCPR;J-019259;Q27275073;Z425795034

Chemical Property of 3-(2-Hydroxyethyl)-2-oxazolidinone

Chemical Property:

• Vapor Pressure: 2.55E-07mmHg at 25°C
• Refractive Index: 1.497
• Boiling Point: 379.6 °C at 760 mmHg
• Flash Point: 183.4 °C
• PSA: 49.77000
• Density: 1.28 g/cm³
• LogP: -0.63120
• Storage Temp.: 2-8°C
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 131.058243149
• Heavy Atom Count: 9
• Complexity: 115

Purity/Quality:

99.9% ^*data from raw suppliers

3-(2-Hydroxyethyl)-1,3-oxazolidin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(=O)N1CCO

Technology Process of 3-(2-Hydroxyethyl)-2-oxazolidinone

There total 3 articles about 3-(2-Hydroxyethyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethylene glycol (107-21-1) + urea (57-13-6) → [1,3]-dioxolan-2-one (96-49-1) + dimethylenecyclourethane (497-25-6) + imidazolidone (120-93-4) + N-(2'-hydroxyethyl)-2-oxazolidone (3356-88-5) + 2-hydroxyethyl carbamate (5395-01-7)

Guidance literature:

With 1-hexadecyl-3-methylimidazolium chloride; zinc(II) chloride; In neat (no solvent); at 140 ℃; under 375.038 Torr; Pressure; Green chemistry;

DOI:10.1016/j.molliq.2020.113883

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 2,2'-iminobis[ethanol] (111-42-2) + 2-methyl-but-3-yn-2-ol (115-19-5) → N-(2'-hydroxyethyl)-2-oxazolidone (3356-88-5) + 3-Hydroxy-3-methyl-2-butanone (115-22-0)

Guidance literature:

With silver carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In chloroform; at 60 ℃; for 18h; under 7500.75 Torr;

DOI:10.1002/cssc.201600470

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 2,2'-iminobis[ethanol] (111-42-2) → 1,4-bis(2-hydroxyethyl)piperazine (122-96-3) + N-(2'-hydroxyethyl)-2-oxazolidone (3356-88-5)

Guidance literature:

With alumina; In ethanol; at 250 ℃; under 112511 Torr; Concentration; Temperature; Pressure; Catalytic behavior; High pressure; Flow reactor; Supercritical conditions;

DOI:10.3762/bjoc.13.36

upstream raw materials:

carbon dioxide

2,2'-iminobis[ethanol]

2-methyl-but-3-yn-2-ol

ethylene glycol

Downstream raw materials:

3-(2-chloroethyl)-2-oxazolidinone

(2-oxo-1,3-oxazolidin-3-yl)acetic acid

acrylic acid 2-(2-oxo-oxazolidin-3-yl)-ethyl ester

1,4-bis(2-hydroxyethyl)piperazine

Refernces

• 1、 Cheng, Weiguo,Deng, Lili,Dong, Li,He, Hongyan,Li, Zengxi,Qian, Wei,Shi, Zijie,Su, Qian,Sun, Wenzhong. "Highly synergistic effect of ionic liquids and Zn-based catalysts for synthesis of cyclic carbonates from urea and diols". . . Retrieved 2020/08/06.
• 2、 Li, Xue-Dong,Song, Qing-Wen,Lang, Xian-Dong,Chang, Yao,He, Liang-Nian. "AgI/TMG-Promoted Cascade Reaction of Propargyl Alcohols, Carbon Dioxide, and 2-Aminoethanols to 2-Oxazolidinones". . p. 3182 - 3188. Retrieved 2017/10/03.