N-(2,4-Dichlorobenzoyl)glycine

Base Information

• Chemical Name: N-(2,4-Dichlorobenzoyl)glycine
• CAS No.: 7554-79-2
• Molecular Formula: C9H7 Cl2 N O3
• Molecular Weight: 248.06
• Hs Code.: 2924299090
• European Community (EC) Number: 849-521-2
• DSSTox Substance ID: DTXSID40352656
• Wikidata: Q82129913
• Mol file: 7554-79-2.mol

Synonyms:7554-79-2;N-(2,4-Dichlorobenzoyl)glycine;2-[(2,4-dichlorobenzoyl)amino]acetic acid;2-(2,4-Dichlorobenzamido)acetic acid;(2,4-Dichloro-benzoylamino)-acetic acid;MFCD00619713;2-[(2,4-dichlorophenyl)formamido]acetic acid;N-[(2,4-dichlorophenyl)carbonyl]glycine;Glycine, N-(2,4-dichlorobenzoyl)-;Oprea1_103970;Oprea1_823579;AO-854/40002776;SCHEMBL11380224;DTXSID40352656;N-(2,4-dichlorobenzoyl) glycine;2-(2,4-Dichlorobenzamido)aceticacid;BBL025896;STL354235;AKOS000114532;HY-W027101;(2,4-Dichloro-benzoylamino)acetic acid;[(2,4-dichlorobenzoyl)amino]acetic acid;CS-0071125;FT-0680439;EN300-00091;(2,4-DICHLORO-BENZOYLAMINO)-ACETICACID;5E-925;SR-01000410073;SR-01000410073-1;[(2,4-Dichlorobenzoyl)amino]acetic acid, AldrichCPR;Z56823545;F1085-0016

Chemical Property of N-(2,4-Dichlorobenzoyl)glycine

Chemical Property:

• Vapor Pressure: 1.9E-08mmHg at 25°C
• Melting Point: 156-160°C
• Boiling Point: 438.1°C at 760 mmHg
• Flash Point: 218.7°C
• PSA: 66.40000
• Density: 1.505g/cm³
• LogP: 2.19870
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 246.9802985
• Heavy Atom Count: 15
• Complexity: 260

Purity/Quality:

98%min ^*data from raw suppliers

[(2,4-Dichlorobenzoyl)amino]acetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)C(=O)NCC(=O)O

Technology Process of N-(2,4-Dichlorobenzoyl)glycine

There total 3 articles about N-(2,4-Dichlorobenzoyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichlorobenzoyl chloride (89-75-8) + glycine (56-40-6,18875-39-3,25718-94-9) → N-(2,4-dichloro-benzoyl)-glycine (7554-79-2)

Guidance literature:

the presence of alkali;

Reference yield:

2,4 dichlorobenzoic acid (50-84-0) → N-(2,4-dichloro-benzoyl)-glycine (7554-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride; triethylamine / CH₂Cl₂

2: triethylamine / CH₂Cl₂

With oxalyl dichloride; triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2004.01.094

Reference yield:

→ N-(2,4-dichloro-benzoyl)-glycine (7554-79-2)

Guidance literature:

Glycin, 2,4-Dichlorbenzoylchlorid, wsr. K2CO3;

upstream raw materials:

2,4-dichlorobenzoyl chloride

glycine

2,4 dichlorobenzoic acid

Downstream raw materials:

2-(2,4-Dichlor-phenyl)-4-furfuryliden-oxazolinon-5

4-(2-chloro-benzylidene)-2-(2,4-dichloro-phenyl)-4H-oxazol-5-one

4-benzylidene-2-(2,4-dichloro-phenyl)-4H-oxazol-5-one

2,4-Dichloro-N-(p-tolylcarbamoyl-methyl)-benzamide

Refernces

• 1、 Tandon, Manish,Coffen, David L.,Gallant, Paul,Keith, Dennis,Ashwell, Mark A.. "Potent and selective inhibitors of bacterial methionyl tRNA synthetase derived from an oxazolone-dipeptide scaffold". . p. 1909 - 1911. Retrieved 2007/10/03.