4-BENZOYLDIHYDRO-2(3H)-FURANONE

Base Information

• Chemical Name: 4-BENZOYLDIHYDRO-2(3H)-FURANONE
• CAS No.: 21034-22-0
• Molecular Formula: C11H10O3
• Molecular Weight: 190.1953
• Hs Code.: 2932209090
• Mol file: 21034-22-0.mol

Synonyms:Butyricacid, 3-benzoyl-4-hydroxy-, g-lactone (7CI);4-Benzoyldihydrofuran-2-one;NSC 23703;b-Benzoyl-g-butyrolactone;

Chemical Property of 4-BENZOYLDIHYDRO-2(3H)-FURANONE

Chemical Property:

• Vapor Pressure: 5.47E-06mmHg at 25°C
• Melting Point: 62-64 °C
• Refractive Index: 1.563
• Boiling Point: 380.4 °C at 760 mmHg
• Flash Point: 173 °C
• PSA: 43.37000
• Density: 1.24 g/cm³
• LogP: 1.43240

Purity/Quality:

98%min ^*data from raw suppliers

4-benzoyldihydro-2(3H)-furanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BENZOYLDIHYDRO-2(3H)-FURANONE

There total 8 articles about 4-BENZOYLDIHYDRO-2(3H)-FURANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + succinylbenzene (2051-95-8) → β-benzoyl-γ-butyrolactone (21034-22-0) + 3-Benzoyl-3-butenoic Acid (76593-29-8) + 4-Benzoyl-4-hydroxymethyl-dihydro-furan-2-one (76593-32-3)

Guidance literature:

With sodium hydroxide; for 1h; Product distribution; Ambient temperature; different molar ratios of reagents;

DOI:10.1055/s-1980-29223

Reference yield: 15.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + succinylbenzene (2051-95-8) → β-benzoyl-γ-butyrolactone (21034-22-0) + 3-Benzoyl-3-butenoic Acid (76593-29-8)

Guidance literature:

With sodium hydroxide; for 1h; Ambient temperature;

DOI:10.1055/s-1980-29223

Reference yield:

3-Hydroxymethyl-4-oxo-4-phenyl-butyric acid ethyl ester → β-benzoyl-γ-butyrolactone (21034-22-0)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; at 25 ℃; for 15h; Yield given;

DOI:10.1021/jo00213a035

upstream raw materials:

formaldehyd

succinylbenzene

(Z)-4-Phenyl-4-trimethylsilanyloxy-but-3-enoic acid ethyl ester

Downstream raw materials:

ethyl 3-benzoyl-3-butenoate

4-Benzoyl-N-<5(6)-(2-methoxycarbonylamino)-benzimidazolyl>pyrrolidin-2-one

1-(3,4-Diaminophenyl)-4-benzoylpyrrolidin-2-one

5-Methyl-6-phenyl-3(2H)-pyridazinone

Refernces

• 1、 Bromhead, Liam J.,Smith, Jason,McErlean, Christopher S.P.. "Chemistry of the Synthetic Strigolactone Mimic GR24". . p. 1221 - 1227. Retrieved 2015/08/18.
• 2、 Barlocco,Martini,Pinna,Curzu,Sala,Germini. "Antihypertensive and antithrombotic activities of 6-(substituted phenyl)-5-hydroxymethyl-4,5-dihydro-3(2H)pyridazinones". . p. 585 - 594. Retrieved 2007/10/02.