2-(4-methoxyphenyl)-2-oxoethyl benzoate

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-2-oxoethyl benzoate
• CAS No.: 41499-11-0
• Molecular Formula: C16H14O4
• Molecular Weight: 270.285
• Mol file: 41499-11-0.mol

Synonyms:NSC 79398;a-(Benzoyloxy)-4-methoxyacetophenone;2-(4-Methoxyphenyl)-2-oxoethyl benzoate;

Chemical Property of 2-(4-methoxyphenyl)-2-oxoethyl benzoate

Chemical Property:

• Vapor Pressure: 3.14E-08mmHg at 25°C
• Refractive Index: 1.567
• Boiling Point: 448.3 °C at 760 mmHg
• Flash Point: 200.4 °C
• Density: 1.189 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-methoxyphenyl)-2-oxoethyl benzoate

There total 10 articles about 2-(4-methoxyphenyl)-2-oxoethyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

benzoic acid (65-85-0,8013-63-6) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → 2-benzoyloxy-1-(4-methoxyphenyl)ethanone (41499-11-0)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In dichloromethane; water; at 20 ℃;

DOI:10.1021/acs.orglett.0c02117

Reference yield: 89.0%

α-tosyloxy-p-methoxyacetophenone (93435-57-5) + Potassium benzoate (582-25-2) → 2-benzoyloxy-1-(4-methoxyphenyl)ethanone (41499-11-0)

Guidance literature:

With 1-butyl-3-methylimidazolium Tetrafluoroborate; at 20 ℃; for 0.333333h;

Reference yield: 85.0%

rac-1-(4-methoxyphenyl)-ethanol (3319-15-1) + benzoic acid (65-85-0,8013-63-6) → 2-benzoyloxy-1-(4-methoxyphenyl)ethanone (41499-11-0)

Guidance literature:

rac-1-(4-methoxyphenyl)-ethanol; benzoic acid; With N-Bromosuccinimide; In 1,4-dioxane; at 60 ℃; for 1h; Sealed tube;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; at 60 ℃; for 4h;

DOI:10.1039/c6ob02173e

upstream raw materials:

sodium benzoate

2-Bromo-4'-methoxyacetophenone

α-tosyloxy-p-methoxyacetophenone

benzoic acid

Downstream raw materials:

1-(4-methoxyphenyl)ethanone

diethyl (1-(4-methoxyphenyl)vinyl)phosphate

Refernces

• 1、 -. "Method for preparing alpha-acyloxy ketone compound". Paragraph 0026. . Retrieved 2017/04/28.
• 2、 Mondal, Buddhadeb,Sahoo, Subas Chandra,Pan, Subhas Chandra. "NBu4NI-catalyzed α-benzoxylation of ketones with terminal aryl alkenes". . p. 3135 - 3140. Retrieved 2015/05/13.