Ethyl 3-(4-aminophenyl)acrylate

Base Information

• Chemical Name: Ethyl 3-(4-aminophenyl)acrylate
• CAS No.: 5048-82-8
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Hs Code.: 29163990
• Mol file: 5048-82-8.mol

Synonyms:Ethyl 3-(4-aminophenyl)acrylate;ETHYL-4-AMINOCINNAMATE;Ethyl-p-amino-cinnamate;Enamine_000582;p-amino cinnamic ethyl ester;4-(ethoxycarbonylvinylene)-aniline;3-(4-aminophenyl)propenoic acid ethyl ester;FT-0617572

Chemical Property of Ethyl 3-(4-aminophenyl)acrylate

Chemical Property:

• Appearance/Colour: slight yellow or off white crystalline
• Vapor Pressure: 5.52E-05mmHg at 25°C
• Melting Point: 70-74 °C(lit.)
• Refractive Index: 1.594
• Boiling Point: 347 °C at 760 mmHg
• PKA: 2.89±0.10(Predicted)
• Flash Point: 192.9 °C
• PSA: 52.32000
• Density: 1.13 g/cm³
• LogP: 2.42630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 191.094628657
• Heavy Atom Count: 14
• Complexity: 205

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 4-aminocinnamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C=CC1=CC=C(C=C1)N

Technology Process of Ethyl 3-(4-aminophenyl)acrylate

There total 25 articles about Ethyl 3-(4-aminophenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ (E)-ethyl 3-(4-aminophenyl)acrylate (5048-82-8,198195-25-4)

Guidance literature:

Reference yield: 99.0%

ethyl 4-nitrocinnamate (953-26-4) → ethyl 4-aminocinnamate (5048-82-8,198195-25-4)

Guidance literature:

With hydrogen; In 2-methyltetrahydrofuran; water; at 40 ℃; for 24h; under 15001.5 Torr; chemoselective reaction;

DOI:10.1039/c8cy01634h

Reference yield: 95.2%

methyl 4-nitrocinnamate (637-57-0,1608-36-2,19310-31-7) → ethyl 4-aminocinnamate (5048-82-8,198195-25-4)

Guidance literature:

With hydrogen; In isopropyl alcohol; at 100 ℃; for 1.33333h; under 34.5 - 40 Torr; Temperature; Reagent/catalyst; Pressure; Inert atmosphere;

upstream raw materials:

ethanol

p-aminocinnamic acid

ethyl 4-nitrocinnamate

trans-p-aminocinnamic acid

Downstream raw materials:

4-(4-phenyl-benzylidenamino)-trans-cinnamic acid ethyl ester

(2E)-3-[4-(isonicotinoylamino)phenyl]-2-propenoic acid

Refernces

• 1、 Dai, Xingchao,He, Dongcheng,Li, Teng,Shi, Feng,Wang, Hongli,Wang, Tao,Wang, Xinzhi. "Efficient hydrogenation catalyst designing via preferential adsorption sites construction towards active copper". . p. 397 - 406. Retrieved 2021/07/21.
• 2、 Agostini, Giovanni,Calvino, Jose. J.,Corma, Avelino,Gutiérrez-Tarri?o, Silvia,Lopes, Christian W.,O?a-Burgos, Pascual,Rojas-Buzo, Sergio. "Cobalt nanoclusters coated with N-doped carbon for chemoselective nitroarene hydrogenation and tandem reactions in water". supporting information. p. 4490 - 4501. Retrieved 2021/06/28.