Anagrelide hydrochloride

Base Information Edit

Chemical Name:Anagrelide hydrochloride
CAS No.:58579-51-4
Molecular Formula:C10H8Cl3N3O
Molecular Weight:292.552
Hs Code.:2933990090
Mol file:58579-51-4.mol

Synonyms:Imidazo[2,1-b]quinazolin-2(3H)-one,6,7-dichloro-1,5-dihydro-, monohydrochloride (9CI);6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one Hydrochloride;Agrelin;Agrylin;BL 4162A;BMY 26538-01;

Suppliers and Price of Anagrelide hydrochloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Anagrelide, Hydrochloride
10mg
$ 355.00

Usbiological
Anagrelide hydrochloride
10mg
$ 409.00

TRC
Anagrelide hydrochloride
50mg
$ 275.00

TRC
Anagrelide hydrochloride
5mg
$ 55.00

TRC
Anagrelide hydrochloride
10mg
$ 85.00

TRC
Anagrelide hydrochloride
25mg
$ 160.00

TRC
Anagrelide hydrochloride
100mg
$ 435.00

Tocris
Anagrelide hydrochloride ≥99%(HPLC)
50
$ 423.00

Tocris
Anagrelide hydrochloride ≥99%(HPLC)
10
$ 101.00

Sigma-Aldrich
Anagrelide hydrochloride ≥98% (HPLC)
50mg
$ 400.00

Total 128 raw suppliers

Chemical Property of Anagrelide hydrochloride Edit

Chemical Property:

Appearance/Colour:Off-white powder
Vapor Pressure:7.21E-06mmHg at 25°C
Melting Point:>280 °C
Boiling Point:376.5 °C at 760 mmHg
Flash Point:181.5 °C
PSA：44.70000
Density:1.77g/cm3
LogP:2.43060
Storage Temp.:Desiccate at +4°C
Solubility.:DMSO: soluble1mg/mL, clear (warmed)

Purity/Quality:

98%min ^*data from raw suppliers

Anagrelide, Hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36/37/38
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Description Anagrelide hydrochloride was launched in the US for thrombocytosis (essential or associated with chronic myelogenous leukemia). The imidazoquinazoline derivative can be prepared from 2,5,6-trichloro-3,4-dihydropyrimidine via alkylation with ethyl bromoacetate followed by heating with ethanolic ammonia or treatment of N-(a-amino- 5,6-dichlorobenzyl)glycine ethyl ester with cyanogen bromide. As a result of its anti-cAMP phosphodiesterase (PDE Ⅲ) activity, Anagrelide hydrochloride was initially tested as a platelet aggregation inhibitor. However it was found that at much lower concentrations it became thrombocytopenic. While the mechanism is not fully understood, it did not shorten platelet survival nor inhibit the formation of colony-forming unitsmegakaryocytes (CFU-M) but primarily interfered with the maturation of megakaryocytes (reduction in size with altered ploidy). It did decrease peripheral vascular resistance and had a positive inotropic effect.
Uses A phosphodiesterase inhibitor with antiplatelet activity. Used as an antithrombocythemic. Signal Transduction Agents, Potent PDE3 inhibitor Anagrelide Hydrochloride is a phosphodiesterase inhibitor with antiplatelet activity. Used as an antithrombocythemic. Potent PDE3 inhibitor.

Technology Process of Anagrelide hydrochloride

There total 10 articles about Anagrelide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%