Pyroglutamylhistidine

Base Information

• Chemical Name: Pyroglutamylhistidine
• CAS No.: 32159-22-1
• Molecular Formula: C11H14N4O4
• Molecular Weight: 266.2533
• Hs Code.: 2934999090
• Nikkaji Number: J376.715I
• Mol file: 32159-22-1.mol

Synonyms:pGlu-His;pyroglutamylhistidine

Chemical Property of Pyroglutamylhistidine

Chemical Property:

• Refractive Index: 1.724
• PSA: 124.18000
• Density: 1.65 g/cm³
• LogP: -0.48010
• Storage Temp.: Store at R.T.
• XLogP3: -1.9
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 266.10150494
• Heavy Atom Count: 19
• Complexity: 387

Purity/Quality:

99%+, ^*data from raw suppliers

LH-RH FRAGMENT 1-2 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=O)NC1C(=O)NC(CC2=CN=CN2)C(=O)O
• Isomeric SMILES: C1CC(=O)N[C@@H]1C(=O)N[C@@H](CC2=CN=CN2)C(=O)O
• Uses: L-Pyroglutamyl-L-histidine is used as one of the cancer treatment combination compounds and formulations.

Technology Process of Pyroglutamylhistidine

There total 2 articles about Pyroglutamylhistidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ L-pyroglutamyl-L-histidine (32159-22-1)

Guidance literature:

3-<1-Benzyl-imidazol-5-yl>-N-L-pyroglutaminyl-L-alanin (24), Hydrierung, Pd/C, 80percent wss. EtOH, 24h;

DOI:10.1021/jm00288a005

Reference yield:

→ Nα-(5-oxo-prolyl)-histidine (32159-22-1,117175-44-7)

Guidance literature:

Ester 3, NaOH;

Reference yield: 55.0%

p-hydroxyamphetamine hydrobromide (306-21-8) + L-pyroglutamyl-L-histidine (32159-22-1) → (S)-5-Oxo-pyrrolidine-2-carboxylic acid [(S)-2-[2-(4-hydroxy-phenyl)-acetylamino]-1-(3H-imidazol-4-ylmethyl)-2-oxo-ethyl]-amide

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 24h;

Downstream raw materials:

L-pyroglutamyl-L-histydyl-L-proline thioamide

L-pyroglutamyl-L-histydyl-D-proline thioamide