N-Phenyl-4-methoxybenzamide

Base Information

• Chemical Name: N-Phenyl-4-methoxybenzamide
• CAS No.: 7465-88-5
• Molecular Formula: C14H13NO2
• Molecular Weight: 227.263
• Hs Code.: 2924299090
• Mol file: 7465-88-5.mol

Synonyms:4-methoxy-N-phenylbenzamide;

Chemical Property of N-Phenyl-4-methoxybenzamide

Chemical Property:

• Vapor Pressure: 0.00105mmHg at 25°C
• Boiling Point: 301.5°C at 760 mmHg
• Flash Point: 136.1°C
• PSA: 38.33000
• Density: 1.181g/cm³
• LogP: 3.02050
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-METHOXY-N-PHENYLBENZAMIDE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Phenyl-4-methoxybenzamide

There total 161 articles about N-Phenyl-4-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxybenzoic acid (100-09-4) + aniline (62-53-3) → 4-methoxy-N-phenylbenzamide (7465-88-5)

Guidance literature:

With diphosphorus tetraiodide; In tetrachloromethane; dichloromethane; Heating;

DOI:10.1246/cl.1983.449

Reference yield: 94.0%

carbon monoxide (201230-82-2) + para-iodoanisole (696-62-8) + aniline (62-53-3) → 4-methoxy-N-phenylbenzamide (7465-88-5)

Guidance literature:

With palladium diacetate; triethylamine; In water; at 100 ℃; for 8h; under 5171.62 Torr; Autoclave;

DOI:10.1055/s-2008-1067160

Reference yield: 94.0%

N-(2-chlorophenyl)-4-methoxybenzamide (7465-92-1) → 4-methoxy-N-phenylbenzamide (7465-88-5)

Guidance literature:

With 1-[2-(N-(3-diphenylphosphinopropyl))aminoethyl]pyrrolidine; triethylamine; palladium dichloride; In water; at 100 ℃; for 12h; regioselective reaction;

DOI:10.1055/s-0040-1707116

upstream raw materials:

oxalyl dichloride

diethyl ether

(Z)-(4-methoxyphenyl)(phenyl)methanone oxime

(4-methoxyphenyl)phenylmethanone oxime

Downstream raw materials:

4-(N,N-dimethylamino)-4'-methoxybenzophenone

(4-(diethylamino)phenyl)(4-methoxyphenyl)methanone

N-phenyl-(4-methoxypheny)acetimidoyl chloride

(4-Methoxy-benzoyl)-phenyl-carbamic acid isopropyl ester

Refernces

• 1、 ?wiatkowski, Marcin,Kudelko, Agnieszka,Maj, Anna. "Novel Conjugated s-Tetrazine Derivatives Bearing a 4H-1,2,4-Triazole Scaffold: Synthesis and Luminescent Properties". . . Retrieved 2022/01/20.
• 2、 Singh, Ashmita,Narula, Anudeep Kumar. "Copper and N-Heterocyclic Carbene-Catalyzed Oxidative Amidation of Aldehydes with Amines". supporting information. p. 718 - 722. Retrieved 2021/02/26.