Technology Process of Glycyl-prolyl-arginyl-proline
There total 23 articles about Glycyl-prolyl-arginyl-proline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C20H17NO10S2(2-)*2Na(1+);
With
sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl cyanoglyoxylate-2-oxime;
In
water;
at 20 ℃;
for 0.75h;
With
ethanolamine;
In
water;
for 0.166667h;
C17H13NO10S2(2-)*2Na(1+); C20H17NO10S2(2-)*2Na(1+); C21H22N4O10S2(2-)*2Na(1+);
Further stages;
DOI:10.1002/anie.202003676
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 71 percent / dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HOBt) / dimethylformamide / -10 °C
2: TFA, anisole / 0.75 h / 0 - 20 °C
3: 1.) HCl/dioxane, isoamyl nitrite / 1.) DMF, -10 deg C, 10 min, 2.) DMF, overnight
4: H2, AcOH / Pd / methanol / 12 h
With
hydrogenchloride; hydrogen; benzotriazol-1-ol; acetic acid; methoxybenzene; dicyclohexyl-carbodiimide; trifluoroacetic acid; isopentyl nitrite;
palladium;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.40.3253
- Guidance literature:
-
With
hydrogen; acetic acid;
palladium;
In
methanol;
for 12h;
DOI:10.1248/cpb.40.3253
