6,6DITHIOBISPURINE

Base Information

• Chemical Name: 6,6DITHIOBISPURINE
• CAS No.: 49808-20-0
• Molecular Formula: C10H6 N8 S2
• Molecular Weight: 302.34
• Mol file: 49808-20-0.mol

Synonyms:1H-Purine,6,6'-dithiobis- (9CI); Purine, 6,6'-dithiodi- (7CI); Bis(6-purinyl) disulfide;NSC 166569; NSC 77640

Chemical Property of 6,6DITHIOBISPURINE

Chemical Property:

• Boiling Point: 512°Cat760mmHg
• Flash Point: 263.5°C
• PSA: 159.52000
• Density: 2.06g/cm³
• LogP: 1.81860
• Storage Temp.: Refrigerator
• Solubility.: Aqueous Base (Slightly, Heated), DMSO (Slightly)

Purity/Quality:

> 95% ^*data from raw suppliers

6-MercaptopurineDisulfide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Mercaptopurine Disulfide is an impurity of 6-Mercaptopurine (M225450, monohydrate) which is an immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.

Technology Process of 6,6DITHIOBISPURINE

There total 5 articles about 6,6DITHIOBISPURINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

6H-purine-6-thione (50-44-2) → bis(6-purinyl) disulfide (49808-20-0)

Guidance literature:

With iodine; potassium iodide; In phosphate buffer; at 40 ℃; pH=7.5;

Reference yield:

6-Mercaptopurine (157930-09-1,157930-10-4,157930-11-5,157930-13-7,157930-14-8) → bis(6-purinyl) disulfide (49808-20-0)

Guidance literature:

With iodine; In dimethyl sulfoxide;

DOI:10.1016/j.ijpharm.2014.10.056

Reference yield:

6-Mercaptopurine (157930-09-1,157930-10-4,157930-11-5,157930-13-7,157930-14-8) → C10H6N8S2Se (87025-41-0) + bis(6-purinyl) disulfide (49808-20-0)

Guidance literature:

With hydrogenchloride; selenium(IV) oxide; In water; Product distribution; Equilibrium constant; Thermodynamic data; pH: 2.4-8.8, at different temperatures;

upstream raw materials:

6-Mercaptopurine

6H-purine-6-thione

Refernces

• 1、 Pazderski,Tousek,Sitkowski,Kozerski,Szlyk. "NMR studies of tautomerism and protonation patterns in bis(6-purinyl) disulfide and ionic forms of 6-mercaptopurine". . p. 193 - 210. Retrieved 2008/03/12.