2 6-DIPHENYL-4H-THIOPYRAN-4-ONE 96

Base Information

• Chemical Name: 2 6-DIPHENYL-4H-THIOPYRAN-4-ONE 96
• CAS No.: 1029-96-5
• Molecular Formula: C17H12 O S
• Molecular Weight: 264.348
• Hs Code.: 2934999090
• Mol file: 1029-96-5.mol

Synonyms:2,6-Diphenyl-4H-4-Thiopyranone;2,6-Diphenyl-g-thiapyrone;2,6-Diphenylthiopyran-4-one; NSC 139252

Chemical Property of 2 6-DIPHENYL-4H-THIOPYRAN-4-ONE 96

Chemical Property:

• Vapor Pressure: 2.55E-08mmHg at 25°C
• Melting Point: 126-130℃
• Boiling Point: 450.9°Cat760mmHg
• Flash Point: 259.9°C
• PSA: 45.31000
• Density: 1.238g/cm³
• LogP: 4.44230

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,?6-?Diphenyl-?4H-?thiopyran-?4-?one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2,?6-?Diphenyl-?4H-?thiopyran-?4-?one is a pharmacophore model for novel inhibitors of ubiquitin isopeptidases that induce p53-independent cell death. Dyes and metabolites.

Technology Process of 2 6-DIPHENYL-4H-THIOPYRAN-4-ONE 96

There total 13 articles about 2 6-DIPHENYL-4H-THIOPYRAN-4-ONE 96 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl dithiobenzoate (2168-78-7) + 4-phenyl-4-(methylthio)but-3-en-2-one → 2,6-diphenyl-4H-thiopyran-4-one (1029-96-5)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at -5 ℃; for 0.5h;

DOI:10.1021/jo00063a023

Reference yield: 82.9%

4-oxo-2,6-diphenyl-thiane (37014-01-0) → 2,6-diphenyl-4H-thiopyran-4-one (1029-96-5)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In toluene; at 100 ℃; for 2h;

Reference yield: 72.0%

2,6-diphenyl-4H-thiopyran (57094-07-2) → 2,6-diphenyl-4H-thiopyran-4-one (1029-96-5)

Guidance literature:

With potassium permanganate; In acetone;

DOI:10.1007/BF00515217

upstream raw materials:

1,5-diphenyl-penta-1,4-diyn-3-one

methyl dithiobenzoate

dibenzylideneacetone

2,6-diphenyl-4H-thiopyran

Downstream raw materials:

[(CO)5W(C(OCH₃)CHC₅H₂S(C₆H₅)2)]

2,6-diphenyl-4H-thiopyran-4-thione

2,2',6,6'-tetraphenyl-Δ^4,4'-bithiopyran 1,1,1',1'-tetraoxide

4-((dimethoxyphosphinyl)methyl)-2,6-diphenyl-4-hydroxy-4H-thiopyran 1,1-dioxide

Refernces

• 1、 Drevko,Smushkin,Kharchenko. "Oxidation reactions of 4H-chalcogenopyrans". . p. 777 - 780. Retrieved 1996.
• 2、 Leonard, Kristi,Nelen, Marina,Raghu, Madhavi,Detty, Michael R.. "Chalcogenopyranones from disodium chalcogenide additions to 1,4- pentadiyn-3-ones. The role of enol ethers as intermediates". . p. 707 - 717. Retrieved 2007/10/03.