5-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 5-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 56426-35-8
• Molecular Formula: C11H10 N2 O2
• Molecular Weight: 202.213
• Hs Code.: 2933199090
• Mol file: 56426-35-8.mol

Synonyms:Pyrazole-3(or5)-carboxylic acid, 5(or 3)-phenyl-, methyl ester (7CI); Methyl5-phenyl-1H-pyrazole-3-carboxylate

Chemical Property of 5-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 2.49E-07mmHg at 25°C
• Melting Point: 180～182℃
• Boiling Point: 422°C at 760 mmHg
• Flash Point: 209°C
• PSA: 54.98000
• Density: 1.231g/cm³
• LogP: 1.86330
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl5-Phenyl-1H-pyrazole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER

There total 27 articles about 5-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(E)-methyl 2-diazo-4-phenylbut-3-enoate (119987-21-2) → methyl 5-phenyl-1H-pyrazole-3-carboxylate (56426-35-8)

Guidance literature:

With dimethyl sulfoxide; at 75 ℃;

DOI:10.1016/j.tetlet.2016.01.020

Reference yield: 96.0%

sodium 4-methoxy-3,4-dioxo-1-phenylbut-1-enolate → 3-phenylpyrazole-5-carboxylic acid methyl ester (56426-35-8,856061-37-5)

Guidance literature:

With hydrazine hydrate; acetic acid; In ethanol; for 24h;

DOI:10.1055/s-0037-1611824

Reference yield: 95.0%

5-Phenyl-2-trimethylsilanyl-2H-pyrazole-3-carboxylic acid methyl ester (94111-13-4) → 3-phenylpyrazole-5-carboxylic acid methyl ester (56426-35-8,856061-37-5)

Guidance literature:

With water; for 12h;

upstream raw materials:

methyl diazoacetate

phenylacetylene

methyl 4-oxo-4-phenylbut-2-ynoate

sodium methylate

Downstream raw materials:

1-Methyl-3-phenylpyrazol-5-carbonsaeure-methylester

C₁₁H₉BrN₂O₂

5-phenyl-1⁽²⁾H-pyrazole-3-carbaldehyde

3-phenyl-1H-pyrazole-5-carboxylic acid

Refernces

• 1、 Ye, Jiqing,Lin, Lin,Xu, Jinyi,Chan, Paul Kay-Sheung,Yang, Xiao,Ma, Cong. "Design, synthesis, biological evaluation and in silico studies of pyrazole‐based nh2‐acyl oseltamivir analogues as potent neuraminidase inhibitors". . . Retrieved 2021/05/05.
• 2、 -. "FUSED TRICYCLIC PYRAZOLO-DIHYDROPYRAZINYL-PYRIDONE COMPOUNDS AS ANTIVIRALS". Paragraph 00245. . Retrieved 2019/07/13.