Platinum,amminedichloro(cyclohexanamine)-, (SP-4-1)-

Base Information

• Chemical Name: Platinum,amminedichloro(cyclohexanamine)-, (SP-4-1)-
• CAS No.: 159701-67-4
• Molecular Formula: C₆H₁₆Cl₂N₂Pt
• Molecular Weight: 382.192
• Mol file: 159701-67-4.mol

Synonyms:JM 334;trans-Amminedichloro(cyclohexylamine)platinum

Chemical Property of Platinum,amminedichloro(cyclohexanamine)-, (SP-4-1)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Platinum,amminedichloro(cyclohexanamine)-, (SP-4-1)-

There total 8 articles about Platinum,amminedichloro(cyclohexanamine)-, (SP-4-1)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

potassium amminetrichloroplatinate + potassium chloride + cyclohexylamine (108-91-8,157973-60-9) → cis-dichloro-trans-ammonia(cyclohexylamine)platinum (159701-67-4,99038-38-7,174691-91-9)

Guidance literature:

With KI; AgNO₃; In water; dropwise addn. of amine to mixt. of Pt-complex and KI, stirring for 1 h (pptn.), collection (filtration), washing (water), drying in air, dissoln. in water, treatment with AgNO3 (in dark, overnight), stirring with KCl at 40°C for 1 h; pptn. on standing at 4°C overnight, filtration, recrystn. (0.01 MHCl, 80°C);

DOI:10.1021/ic960983u

Reference yield: 80.0%

hydrogenchloride (7647-01-0,15364-23-5) + cisplatin (15663-27-1) + cyclohexylamine (108-91-8,157973-60-9) → trans-[PtCl2(NH3)(cyclohexylamine)] (159701-67-4,99038-38-7,174691-91-9)

Guidance literature:

In water; stirring Pt-complex with 2 equiv. of amine at 70°C, then refluxing, cooling to room temp., addn. of 12 M HCl, refluxing for 6 h; crystn. on cooling in ice, filtration, washing (H2O); elem. anal.;

Reference yield: 63.3%

hydrogenchloride (7647-01-0,15364-23-5) + C6H16ClIN2Pt → cis-dichloro-trans-ammonia(cyclohexylamine)platinum (159701-67-4,99038-38-7,174691-91-9)

Guidance literature:

C₆H₁₆ClIN₂Pt; With silver nitrate; In water; at 20 ℃; for 5h;

hydrogenchloride; In water; at 20 ℃;

DOI:10.1016/j.ica.2014.07.043

upstream raw materials:

cis-Pt(NH₃)(cyclohexylamine)I₂

cyclohexylamine

(SP-4-3)-amminechloro(cyclohexanamine)iodoplatinum(II)

cis,trans,cis-PtCl₂(OCOC₃H₇)2(cyclohexylamine)NH₃

Downstream raw materials:

[PtCl(NH₃)(C₆H₁₁NH₂)(H₂O)]⁽¹⁺⁾

PtCl(NH₃)(cyclohexylamine)(OH)

trans-Pt(N₃)2(NH₃)(cyclohexamine)

cis-[Pt(OH)4NH₃(c-C₆H₁₁NH₂)]

Refernces

• 1、 Shi, Yi,Koneru, Bhuvaneswari,Redfearn, Warren,Miller, Michael L.,Myers, Lara,Di Pasqua, Anthony J.. "Platinum(IV) cisplatin derivative trans, cis, cis-bis(heptanoato)amine(cyclohexylamine)dichloridoplatinum(IV) has an enhanced therapeutic index compared to cisplatin for the treatment of non-small cell lung cancer". . p. 215 - 219. Retrieved 2014.
• 2、 Barton, Sarah J.,Barnham, Kevin J.,Habtemariam, Abraha,Sue, Rodney E.,Sadler, Peter J.. "pKa values of aqua ligands of platinum(II) anticancer complexes: [1H, 15N] and 195Pt NMR studies of cis- and trans-[PtCl2 (NH3)(cyclohexylamine)]". . p. 8 - 13. Retrieved 2008/10/08.