(2,4-Dimethoxyphenyl)(4-methoxyphenyl)methanone

Base Information

• Chemical Name: (2,4-Dimethoxyphenyl)(4-methoxyphenyl)methanone
• CAS No.: 4038-15-7
• Molecular Formula: C16H16 O4
• Molecular Weight: 272.301
• Hs Code.: 2914509090
• NSC Number: 78015
• DSSTox Substance ID: DTXSID40291793
• Nikkaji Number: J2.806.602C
• Wikidata: Q82029852
• ChEMBL ID: CHEMBL1608361
• Mol file: 4038-15-7.mol

Synonyms:4038-15-7;(2,4-dimethoxyphenyl)(4-methoxyphenyl)methanone;2,4,4'-TRIMETHOXYBENZOPHENONE;(2,4-dimethoxyphenyl)-(4-methoxyphenyl)methanone;(2,4-dimethoxy-phenyl)-(4-methoxy-phenyl)-methanone;NSC78015;Maybridge1_005563;Oprea1_837791;MLS000861006;DivK1c_001851;SCHEMBL5902231;CHEMBL1608361;HMS557E19;DTXSID40291793;VFTDVICZBGDMMB-UHFFFAOYSA-N;BDBM152505;MFCD00100089;NSC-78015;2,4-dimethoxy-4'-methoxybenzophenone;AKOS009159039;2, 4-dimethoxy-4'-methoxybenzophenone;CDS1_000811;AS-67576;SMR000459790;CS-0150424;FT-0609775;EN300-73302;D97417;(2,4-dimethoxyphenyl)(4-methoxyphenyl)methanone (18);Z385418350

Chemical Property of (2,4-Dimethoxyphenyl)(4-methoxyphenyl)methanone

Chemical Property:

• Melting Point: 71-73°C
• Boiling Point: 444°Cat760mmHg
• Flash Point: 197.9°C
• PSA: 44.76000
• Density: 1.136g/cm³
• LogP: 2.94340
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 272.10485899
• Heavy Atom Count: 20
• Complexity: 310

Purity/Quality:

99% ^*data from raw suppliers

(2,4-Dimethoxy-phenyl)-(4-methoxy-phenyl)-methanone ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C2=C(C=C(C=C2)OC)OC

Technology Process of (2,4-Dimethoxyphenyl)(4-methoxyphenyl)methanone

There total 9 articles about (2,4-Dimethoxyphenyl)(4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-methoxybenzoic acid (100-09-4) + 1,3-Dimethoxybenzene (151-10-0) → 2,4,4'-trimethoxybenzophenone (4038-15-7)

Guidance literature:

With PPA; at 90 ℃; for 8h;

DOI:10.1016/0040-4020(96)00815-0

Reference yield: 79.0%

1-iodo-2,4-dimethoxybenzene (20469-63-0) + 4-methoxyphenylboronic acid (5720-07-0) + 9-methyl-9H-fluorene-9-carbonyl chloride (82102-37-2) → 2,4,4'-trimethoxybenzophenone (4038-15-7)

Guidance literature:

9-methyl-9H-fluorene-9-carbonyl chloride; With N-ethyl-N,N-diisopropylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; at 80 ℃;

1-iodo-2,4-dimethoxybenzene; 4-methoxyphenylboronic acid; With potassium carbonate; palladium dichloride; at 80 ℃;

DOI:10.1021/jo401696c

Reference yield: 76.0%

1-(4-methoxybenzoyl)piperidine-2,6-dione + (2,4-dimethoxyphenyl)zinc chloride (109384-40-9) → 2,4,4'-trimethoxybenzophenone (4038-15-7)

Guidance literature:

1-(4-methoxybenzoyl)piperidine-2,6-dione; With bis(triphenylphosphine)nickel(II) chloride; In diethyl ether; at 23 ℃; for 0.0833333h; Inert atmosphere; Schlenk technique;

(2,4-dimethoxyphenyl)zinc chloride; In tetrahydrofuran; diethyl ether; at 23 ℃; for 12h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201602202

upstream raw materials:

2,4-dimethoxybenzoyl chloride

methoxybenzene

4-methoxybenzoic acid

1,3-Dimethoxybenzene

Downstream raw materials:

(2,4-Dimethoxy-phenyl)-(4-methoxy-phenyl)-phenyl-methanol

2,4,4'-trihydroxy-benzophenone

2,4-dimethoxy-1-(4-methoxybenzyl)benzene

2-hydroxy-4,4'-dimethoxybenzophenone

Refernces

• 1、 Demir, Yeliz,Taslimi, Parham,Ozaslan, Muhammet Serhat,Oztaskin, Necla,?etinkaya, Yasin,Gul?in, ?lhami,Beydemir, ?ükrü,Goksu, Suleyman. "Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes". . . Retrieved 2018/12/04.
• 2、 Shi, Shicheng,Szostak, Michal. "Efficient Synthesis of Diaryl Ketones by Nickel-Catalyzed Negishi Cross-Coupling of Amides by Carbon–Nitrogen Bond Cleavage at Room Temperature Accelerated by a Solvent Effect". supporting information. p. 10420 - 10424. Retrieved 2016/07/21.