Trientine HCl

Base Information

• Chemical Name: Trientine HCl
• CAS No.: 38260-01-4
• Molecular Formula: C6H20Cl2N4
• Molecular Weight: 219.158
• Hs Code.: 2921290055
• NSC Number: 759164,158271
• DSSTox Substance ID: DTXSID80419994
• ChEMBL ID: CHEMBL1200783
• Mol file: 38260-01-4.mol

Synonyms:Trientine HCl;21121-06-2;N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine;hydrochloride;triethylenetetramine HCl;SMR000058543;MLS000069683;SCHEMBL205201;CHEMBL1200783;DTXSID80419994;XPVOJYDIBHYVFL-UHFFFAOYSA-N;Pharmakon1600-01505675;NSC158271;NSC759164;1, N,N'-bis(2-aminoethyl)-, tetrahydrochloride

Chemical Property of Trientine HCl

Chemical Property:

• Appearance/Colour: white crystalline powder
• Melting Point: 120-125 °C (dec.)
• Boiling Point: 266.5 °C at 760 mmHg
• Flash Point: 143.3 °C
• PSA: 76.10000
• Density: 0.958 g/cm³
• LogP: 1.86940
• Storage Temp.: 0-6°C
• Solubility.: Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 182.1298243
• Heavy Atom Count: 11
• Complexity: 49.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

Trientine hydrochloride United States Pharmacopeia (USP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(CNCCNCCN)N.Cl
• Description: Trientine hydrochloride is a copper chelating agent recommended for the treatment of Wilson's Disease, especially in patients intolerant of penicillamine therapy. Unlike the latter agent, trientine is not indicated in cystinuria or rheumatoid arthritis.
• Uses: Triethylenetetramine Hydrochloride is a selective CuII-chelator; crosslinking agent. Triethylenetetramine is undergoing trials for the treatment of heart failure in patients with diabetes. antibacterial As thermosetting resin; epoxy curing agent; lubricating oil additive; analytical reagent for Cu, Ni.

Technology Process of Trientine HCl

There total 9 articles about Trientine HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C16H34N4O4*2C4H4O4 → N,N'-bis(2-aminoethyl)ethane-1,2-diamine dihydrochloride (38260-01-4)

Guidance literature:

C₁₆H₃₄N₄O₄*2C₄H₄O₄; With hydrogenchloride; In water; at 25 - 70 ℃;

With sodium carbonate; In methanol; at 20 - 30 ℃; for 2h; Reagent/catalyst; Solvent;

Reference yield: 88.0%

C16H34N4O4 (1044159-20-7) → N,N'-bis(2-aminoethyl)ethane-1,2-diamine dihydrochloride (38260-01-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 25 ℃; for 1h; Time;

Reference yield: 82.0%

1,3-bis-(2-benzylidenamino-ethyl)-2-phenyl-imidazolidine (81904-67-8) → N,N'-bis(2-aminoethyl)ethane-1,2-diamine dihydrochloride (38260-01-4)

Guidance literature:

With hydrogenchloride; water; Product distribution / selectivity;

upstream raw materials:

triethylenetetramine tetrahydrochloride

1,3-bis-(2-benzylidenamino-ethyl)-2-phenyl-imidazolidine

tert-butyl N-(2-aminoethyl)-N-[2-(2-aminoethyl(tert-butoxycarbonyl)amino)ethyl]carbamate

C₁₆H₃₄N₄O₄

Downstream raw materials:

triethylentetramine

Refernces

• 1、 -. "A PROCESS FOR THE PREPARATION OF TRIENTINE DIHYDROCHLORIDE". Page/Page column 15; 16. . Retrieved 2019/05/02.
• 2、 -. "IMPROVED METHOD FOR THE SYNTHESIS OF 1,2-ETHANEDIAMINE, N, N'-BIS(2-AMINOETHYL)-DIHYDROCHLORIDE(TRIENTINE DIHYDROCHLORIDE)". Page/Page column 18; 20; 21. . Retrieved 2018/11/22.