2-methyl-5-phenyl-1,3,4-oxadiazole

Base Information

• Chemical Name: 2-methyl-5-phenyl-1,3,4-oxadiazole
• CAS No.: 4046-03-1
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.175
• Hs Code.: 2934999090
• Mol file: 4046-03-1.mol

Synonyms:

Chemical Property of 2-methyl-5-phenyl-1,3,4-oxadiazole

Chemical Property:

• Vapor Pressure: 0.00618mmHg at 25°C
• Boiling Point: 281.1°C at 760 mmHg
• Flash Point: 126°C
• PSA: 38.92000
• Density: 1.142g/cm³
• LogP: 2.04500

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-5-phenyl-1,3,4-oxadiazole

There total 60 articles about 2-methyl-5-phenyl-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-Phenyl-1H-tetrazole (18039-42-4,3999-10-8) + acetic anhydride (108-24-7) → 2-methyl-5-phenyl-[1,3,4]oxadiazole (4046-03-1)

Guidance literature:

In 1,2-dimethoxyethane; at 220 ℃; for 0.0833333h; under 8250.83 - 10501.1 Torr; Microwave irradiation; Sealed vial;

DOI:10.1016/j.tetlet.2011.12.043

Reference yield: 93.0%

benzoic acid hydrazide (613-94-5) + Triethyl orthoacetate (78-39-7) → 2-methyl-5-phenyl-[1,3,4]oxadiazole (4046-03-1)

Guidance literature:

With sulfuric acid; silica gel; at 20 ℃;

DOI:10.1080/00397910701199151

Reference yield: 93.0%

1-acetyl-2-benzoylhydrazine (14331-27-2) → 2-methyl-5-phenyl-[1,3,4]oxadiazole (4046-03-1)

Guidance literature:

With triphenylphosphine-carbon tetrachloride; triethylamine; In dichloromethane; 1.) room temperature, 30 min, 2.) reflux, 3 h;

upstream raw materials:

1-acetyl-2-benzoylhydrazine

benzoic acid hydrazide

Triethyl orthoacetate

4-methyleneoxetan-2-one

Downstream raw materials:

2-<(hydroxyimino)methyl>-5-phenyl-1,3,4-oxadiazole

4-mesityl-3-methyl-5-phenyl-4H-1,2,4-triazole

(4aR,8aS)-3-Phenyl-5,6,7,8,8a,9-hexahydro-4aH-[1,2,4]triazolo[4,3-a]indole

(4aR,8aR)-3-Phenyl-5,6,7,8,8a,9-hexahydro-4aH-[1,2,4]triazolo[4,3-a]indole

Refernces

• 1、 Artyushkina, Yu. M.,Dushenko, G. A.,Mikhailov, I. E.,Minkina, V. I.. "Synthesis and spectral luminescence properties of 2-aryl-5-methyl-1,3,4-oxadiazoles and zinc(ii) 2-(2-hydroxyphenyl)-5-methyl-1,3,4-oxadiazole complex". . p. 176 - 178. Retrieved 2020/04/17.
• 2、 Lu, Fangling,Gong, Fengping,Li, Liangsen,Zhang, Kan,Li, Zhen,Zhang, Xinwei,Yin, Ying,Wang, Ying,Gao, Ziwei,Zhang, Heng,Lei, Aiwen. "Electrochemical Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles from α-Keto Acids and Acylhydrazines Under Mild Conditions". supporting information. p. 3257 - 3260. Retrieved 2020/05/25.