diazoketone methotrexate

Base Information

• Chemical Name: diazoketone methotrexate
• CAS No.: 82972-54-1
• Molecular Formula: C₂₁H₂₂N₁₀O₄
• Molecular Weight: 478.47
• Mol file: 82972-54-1.mol

Synonyms:Methotrexate diazoketone analog;Diazoketone methotrexate;

Chemical Property of diazoketone methotrexate

Chemical Property:

• PSA: 225.91000
• LogP: 0.35268

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diazoketone methotrexate

There total 1 articles about diazoketone methotrexate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-diazo-5-oxo-L-norleucine (157-03-9,7390-76-3,764-17-0) + 4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid (19741-14-1) → 4-amino-4-deoxy-N10-methylpteroyl-(6-diazo-5-oxo)-L-norleucine (82972-54-1)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) DMSO, THF, 0 deg C, 1 h; room temperature, 1 h, 2.) 3 h;

DOI:10.1002/jps.2600710631

upstream raw materials:

6-diazo-5-oxo-L-norleucine

4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid

Refernces