2-[4(1H)-PYRIDINYLIDENE]INDAN-1,3-DIONE

Base Information

• Chemical Name: 2-[4(1H)-PYRIDINYLIDENE]INDAN-1,3-DIONE
• CAS No.: 10478-99-6
• Molecular Formula: C14H9NO2
• Molecular Weight: 223.231
• Mol file: 10478-99-6.mol

Synonyms:1,3-Indandione,2-(4-pyridyl)- (8CI);

Chemical Property of 2-[4(1H)-PYRIDINYLIDENE]INDAN-1,3-DIONE

Chemical Property:

• Vapor Pressure: 2.65E-05mmHg at 25°C
• Refractive Index: 1.682
• Boiling Point: 357.9 °C at 760 mmHg
• Flash Point: 148.1 °C
• PSA: 49.93000
• Density: 1.365 g/cm³
• LogP: 1.52570

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-[4(1H)-Pyridinylidene]indan-1,3-dione ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[4(1H)-PYRIDINYLIDENE]INDAN-1,3-DIONE

There total 3 articles about 2-[4(1H)-PYRIDINYLIDENE]INDAN-1,3-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

picoline (108-89-4) + Diethyl phthalate (84-66-2) → 2-(4-pyridyl)-indane-1,3-dione (10478-99-6)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1039/d0cc03408h

Reference yield: 70.0%

picoline (108-89-4) + phthalic anhydride (85-44-9) → 2-(4-pyridyl)-indane-1,3-dione (10478-99-6)

Guidance literature:

With zinc(II) chloride; at 200 ℃; for 5h;

DOI:10.1002/jhet.5570390119

Reference yield:

→ 2-(4-pyridyl)-indane-1,3-dione (10478-99-6)

Guidance literature:

Phthalid, 4-Pyridin-carboxaldehyd, Natriummethylat;

DOI:10.1021/jo01281a064

upstream raw materials:

picoline

phthalic anhydride

Diethyl phthalate

Refernces

• 1、 Mosher,Soeder. "". . p. 1561. Retrieved 1971.
• 2、 Rehse,Brandt. "2-Methylene-1,3-indanediones: Azaaromatic anticoagulants without enolizable carbonyl functions". . p. 54 - 58. Retrieved 2007/10/02.