3-METHOXYCINNAMIC ACID

Base Information

• Chemical Name: 3-METHOXYCINNAMIC ACID
• CAS No.: 17570-26-2
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.188
• Hs Code.: 2916399090
• Mol file: 17570-26-2.mol

Synonyms:2-Propenoicacid, 3-(3-methoxyphenyl)-, (E)-; Cinnamic acid, m-methoxy-, (E)- (8CI);(2E)-3-(3-Methoxyphenyl)-2-propenoic acid; (E)-3-(3-Methoxyphenyl)-2-propenoicacid; (E)-3-Methoxycinnamic acid; (E)-m-Methoxycinnamic acid;trans-3-(3-Methoxyphenyl)-2-propenoic acid; trans-3-Methoxycinnamic acid;trans-m-Methoxycinnamic acid

Chemical Property of 3-METHOXYCINNAMIC ACID

Chemical Property:

• Appearance/Colour: White to light brown fine crystalline powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 116-119 °C(lit.)
• Boiling Point: 329.9 °C at 760 mmHg
• Flash Point: 132.6 °C
• PSA: 46.53000
• Density: 1.195 g/cm³
• LogP: 1.79300
• Storage Temp.: -196°C

Purity/Quality:

99% ^*data from raw suppliers

(2E)-3-(3-Methoxyphenyl)acrylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHOXYCINNAMIC ACID

There total 41 articles about 3-METHOXYCINNAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

malonic acid (141-82-2) + 3-methoxy-benzaldehyde (591-31-1) → trans-3-methoxycinnamic acid (6099-04-3,17570-26-2)

Guidance literature:

With piperidine; pyridine;

DOI:10.1021/jo00279a014

Reference yield: 92.0%

3-methoxy-1-iodobenzene (766-85-8) + acrylic acid (79-10-7) → trans-3-methoxycinnamic acid (6099-04-3,17570-26-2)

Guidance literature:

With potassium carbonate; In water; for 12h; Inert atmosphere; Reflux;

DOI:10.1039/c4nj01581a

Reference yield: 90.0%

3-methoxyphenyl bromide (2398-37-0) + acrylic acid (79-10-7) → trans-3-methoxycinnamic acid (6099-04-3,17570-26-2)

Guidance literature:

With potassium carbonate; In water; for 12h; Inert atmosphere; Reflux;

DOI:10.1039/c4nj01581a

upstream raw materials:

(3-methoxy-benzylidene)-malonic acid

sodium acetate

acetic anhydride

3-methoxy-benzaldehyde

Downstream raw materials:

5-methoxy-2-nitrocinnamic acid

2-nitro-3-methoxy-trans-cinnamic acid

3-(3-Methoxy-4-nitrophenyl)-2-propenoic acid

methyl (E)-3-(3-methoxy-4-nitrophenyl)propenoate

Refernces

• 1、 Li, Peng-Xiao,Liu, Guo-Yun,Liu, Ren-Min,Liu, Yue,Mu, Wen-Wen,Sun, Ya-Lei,Yang, Jie. "Design, Synthesis, and Anticancer Activity of Cinnamoylated Barbituric Acid Derivatives". . . Retrieved 2022/01/13.
• 2、 Zhou, Yu,Fu, Yan,Yin, Wanchao,Li, Jian,Wang, Wei,Bai, Fang,Xu, Shengtao,Gong, Qi,Peng, Tao,Hong, Yu,Zhang, Dong,Zhang, Dan,Liu, Qiufeng,Xu, Yechun,Xu, H. Eric,Zhang, Haiyan,Jiang, Hualiang,Liu, Hong. "Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate". . p. 1844 - 1855. Retrieved 2021/03/01.