Efaproxiral sodium

Base Information

• Chemical Name: Efaproxiral sodium
• CAS No.: 170787-99-2
• Molecular Formula: C20H23NO4 . Na
• Molecular Weight: 363.38
• Hs Code.: 2924299090
• European Community (EC) Number: 811-228-2
• UNII: 3L83QP52XI
• DSSTox Substance ID: DTXSID50168942
• Wikidata: Q27257521
• NCI Thesaurus Code: C72748
• ChEMBL ID: CHEMBL2107744
• Mol file: 170787-99-2.mol

Synonyms:Efaproxiral sodium;170787-99-2;RSR13 SODIUM;Sodium 2-(4-(2-((3,5-dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoate;Efaproxiral (sodium);Efaproxiral Sodium;RSR 13 sodium;Efaproxiral sodium [USAN];UNII-3L83QP52XI;RSR-13 SODIUM;3L83QP52XI;170787-99-2 (sodium);Efaproxiral sodium (USAN);Sodium 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methylpropanoate;Propanoic acid, 2-(4-(2-((3,5-dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methyl-, monosodium salt;sodium;2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoate;2-(4-(2-((3,5-dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid monosodium salt;Revaproxyn;2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methylpropanoic acid monosodium salt;EFAPROXIRALSODIUM;Efaproxiral sodium [USAN];C20H23NO4.Na;SCHEMBL3763811;CHEMBL2107744;C20-H23-N-O4.Na;DTXSID50168942;HMS3652L04;EFAPROXIRAL SODIUM [MART.];BCP07458;EFAPROXIRAL SODIUM [WHO-DD];EX-A4942;HY-13619A;MFCD02093864;s4263;AKOS015896245;sodium 2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoate;AC-5019;CCG-268204;CS-4949;AS-56984;E1356;FT-0658052;SW219343-1;A51048;D03962;A811239;Q27257521;2-(4((((3,5-Dimethylphenyl)amino)carbonyl)methyl)-phenoxy)-2-methyl propionic acid;2-(4-(((3,5-DIMETHYLANILINO)CARBONYL)METHYL)-PHENOXY)-2-METHYLPROPIONIC ACID SODIUM;SODIUM 2-(4-{[(3,5-DIMETHYLPHENYL)CARBAMOYL]METHYL}PHENOXY)-2-METHYLPROPANOATE;sodium,2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoate;2-(4-(2-((3,5-dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid monosodium salt;2-[4-[2-[(3,5-dimethylphenyl) amino]-2-oxoethyl]phenoxy]-2-methylpropanoic acid monosodium salt;sodium 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxidanylidene-ethyl]phenoxy]-2-methyl-propanoate

Chemical Property of Efaproxiral sodium

Chemical Property:

• Vapor Pressure: 3.93E-13mmHg at 25°C
• Melting Point: 240.0 ~244.0 °C
• Boiling Point: 554.5 °C at 760 mmHg
• Flash Point: 289.2 °C
• PSA: 78.46000
• LogP: 2.46490
• Solubility.: ≥12.83 mg/mL in H2O with ultrasonic; ≥18.4 mg/mL in DMSO; ≥18.45 mg/mL in EtOH
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 363.14465246
• Heavy Atom Count: 26
• Complexity: 464

Purity/Quality:

98%,99%, ^*data from raw suppliers

Efaproxiral Sodium ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=C1)NC(=O)CC2=CC=C(C=C2)OC(C)(C)C(=O)[O-])C.[Na+]
• Recent EU Clinical Trials: A Phase 3 Randomized, Open-label Comparative Study of Standard Whole Brain Radiation Therapy with Supplemental Oxygen, with or without Concurrent RSR13 (efaproxiral), in Women with Brain Metastases from Breast Cancer
• Uses: Treatment of clinical conditions characterized by tissue hypoxia including cardiovascular, surgical, and critical care conditions; adjunctive treatment in standard radiation therapy and chemotherapy (synthetic allosteric modifier of hemoglobin.