4-Methyl-N'-[(E)-phenylmethylidene]benzohydrazide

Base Information

• Chemical Name: 4-Methyl-N'-[(E)-phenylmethylidene]benzohydrazide
• CAS No.: 6958-43-6
• Molecular Formula: C15H14 N2 O
• Molecular Weight: 238.289
• NSC Number: 64712
• ChEMBL ID: CHEMBL1170776
• Mol file: 6958-43-6.mol

Synonyms:4-Methyl-N'-[(E)-phenylmethylidene]benzohydrazide;NSC64712;CHEMBL1170776;NFRNQIUUFKWQQG-LFIBNONCSA-N;HMS1580K21;NSC-64712;STK914986;N'-benzylidene-4-methylbenzohydrazide;AKOS002320695;4-Methylbenzenamide, N-benzylidenamino-;NCGC00327595-01;AB01322755-02;SR-01000203600;SR-01000203600-1;4-Methyl-N'-[(E)-phenylmethylidene]benzohydrazide #;Z49680523

Chemical Property of 4-Methyl-N'-[(E)-phenylmethylidene]benzohydrazide

Chemical Property:

• Vapor Pressure: 5.13E-12mmHg at 25°C
• Boiling Point: 546.9°C at 760 mmHg
• Flash Point: 284.6°C
• Density: 1.44g/cm³
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 238.110613074
• Heavy Atom Count: 18
• Complexity: 287

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=O)NN=CC2=CC=CC=C2
• Isomeric SMILES: CC1=CC=C(C=C1)C(=O)N/N=C/C2=CC=CC=C2

Technology Process of 4-Methyl-N'-[(E)-phenylmethylidene]benzohydrazide

There total 2 articles about 4-Methyl-N'-[(E)-phenylmethylidene]benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.3%

benzaldehyde (100-52-7) + p-toluic hydrazide (3619-22-5) → N-benzaldehyde(p-methylbenzoylhydrazone) (6958-43-6)

Guidance literature:

In ethanol; Reflux;

DOI:10.1016/j.ejmech.2010.03.002

Reference yield:

→ Benzyliden-p-methyl-benzohydrazid (6958-43-6,59394-98-8)

Guidance literature:

Benzaldehydhydrazon, entspr. Saeurechlorid;

Reference yield: 89.0%

N-benzaldehyde(p-methylbenzoylhydrazone) (6958-43-6) + 1,1-diphenylprop-2-en-1-ol (3923-51-1) → N'-benzylidene-4-methyl-N-(3-oxo-2,3-diphenylpropyl)benzohydrazide

Guidance literature:

With di-tert-butyl peroxide; In 1,4-dioxane; at 100 ℃; for 8h; Inert atmosphere;

upstream raw materials:

benzaldehyde

p-toluic hydrazide

Downstream raw materials:

trans-[Ru(III)(C₆H₄CHNNC(4-Me-C₆H₄)O)(PPh₃)2Cl]

2-phenyl-3-acetyl-5-(4-methylphenyl)-2,3-dihydro-1,3,4-oxadiazole

2-(4-methylphenyl)-5-phenyl-1,3,4-oxadiazole

Refernces

• 1、 MacCioni, Elias,Alcaro, Stefano,Cirilli, Roberto,Vigo, Sara,Cardia, Maria Cristina,Sanna, Maria Luisa,Meleddu, Rita,Yanez, Matilde,Costa, Giosuè,Casu, Laura,Matyus, Peter,Distinto, Simona. "3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: A new scaffold for the selective inhibition of monoamine oxidase B". experimental part. p. 6394 - 6398. Retrieved 2011/11/06.