1-Isonicotinyl-2-palmitoyl hydrazine

Base Information

• Chemical Name: 1-Isonicotinyl-2-palmitoyl hydrazine
• CAS No.: 101524-04-3
• Molecular Formula: C₂₂H₃₇N₃O₂
• Molecular Weight: 375.555
• DSSTox Substance ID: DTXSID00906295
• Nikkaji Number: J371.910C
• Wikidata: Q82874996
• ChEMBL ID: CHEMBL2443180
• Mol file: 101524-04-3.mol

Synonyms:1-isonicotinyl-2-palmitoyl hydrazine;INH-PALM

Chemical Property of 1-Isonicotinyl-2-palmitoyl hydrazine

Chemical Property:

• Vapor Pressure: 1.09E-12mmHg at 25°C
• Boiling Point: 562.7°C at 760 mmHg
• Flash Point: 294.1°C
• PSA: 71.09000
• Density: 0.997g/cm³
• LogP: 6.10570
• XLogP3: 7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 15
• Exact Mass: 375.28857743
• Heavy Atom Count: 27
• Complexity: 382

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCCCCC(=O)NNC(=O)C1=CC=NC=C1

Technology Process of 1-Isonicotinyl-2-palmitoyl hydrazine

There total 3 articles about 1-Isonicotinyl-2-palmitoyl hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isoniazid (54-85-3,7640-37-1) + n-hexadecanoyl chloride (112-67-4) → N′-hexadecanoylisonicotinohydrazide (101524-04-3)

Guidance literature:

With 1,4-dioxane; pyridine;

DOI:10.1021/jo50016a018

Reference yield:

1-hexadecylcarboxylic acid (57-10-3) → N′-hexadecanoylisonicotinohydrazide (101524-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane / 0.5 h / 20 °C

2: dmap / dichloromethane / 12 h / 20 °C

With dmap; oxalyl dichloride; In dichloromethane;

DOI:10.1016/j.bmc.2013.09.034

Reference yield:

→ N′-hexadecanoylisonicotinohydrazide (101524-04-3)

Guidance literature:

Isonicotinsaeure-hydrazid, Palmitinsaeure-chlorid, Py.;

upstream raw materials:

isoniazid

n-hexadecanoyl chloride

1-hexadecylcarboxylic acid

Refernces

• 1、 Rodrigues, Marieli O.,Cantos, Jéssica B.,D'Oca, Caroline R. Montes,Soares, Karina L.,Coelho, Tatiane S.,Piovesan, Luciana A.,Russowsky, Dennis,Da Silva, Pedro A.,D'Oca, Marcelo G. Montes. "Synthesis and antimycobacterial activity of isoniazid derivatives from renewable fatty acids". . p. 6910 - 6914. Retrieved 2013.