8-CHLOROADENINE

Base Information

• Chemical Name: 8-CHLOROADENINE
• CAS No.: 28128-28-1
• Molecular Formula: C₅H₄ClN₅
• Molecular Weight: 169.573
• Hs Code.: 2933990090
• Mol file: 28128-28-1.mol

Synonyms:1H-Purin-6-amine,8-chloro- (9CI); Adenine, 8-chloro- (6CI,8CI); 8-Chloroadenine; NSC 22712

Chemical Property of 8-CHLOROADENINE

Chemical Property:

• Vapor Pressure: 0.000443mmHg at 25°C
• Boiling Point: 315.2°Cat760mmHg
• Flash Point: 144.4°C
• PSA: 80.48000
• Density: 2.09g/cm³
• LogP: 1.16970
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

≥95% ^*data from raw suppliers

8-Chloroadenine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-CHLOROADENINE

There total 5 articles about 8-CHLOROADENINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

8-Chlor-purin (17587-87-0) → adenine (66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9) + 8-chloro-9H-purin-6-ylamine (28128-28-1)

Guidance literature:

With potassium amide; In ammonia; for 20h;

Reference yield:

adenosine (58-61-7) → 8-chloro-9H-purin-6-ylamine (28128-28-1)

Guidance literature:

With m-chloroperoxybenzoic acid; 3-chloro-benzenecarboperoxoic acid; In hydrogenchloride; water; 2,4-dichlorophenoxyacetic acid dimethylamine; toluene;

Reference yield:

6,8-dichloro-7(9)H-purine (19916-15-5) → 8-chloroadenine (28128-28-1)

Guidance literature:

With ammonium hydroxide; at 100 ℃;

DOI:10.1021/ja01557a051

upstream raw materials:

6,8-dichloro-7(9)H-purine

diceto-6,8 purine

8-Chlor-purin

adenosine

Downstream raw materials:

8-Methoxyadenin

8-chlorohypoxanthine

Refernces

• 1、 Kos, N. J.,Plas, H. C. van der,Veldhuizen, A. van. "The behaviour of 6- and 8-substituted purines toward potassium amide in liquid ammonia. A new example of tele-amination". . p. 267 - 270. Retrieved 2007/10/02.