2-tert-butyl-3,3-dimethylbutanoic acid

Base Information

• Chemical Name: 2-tert-butyl-3,3-dimethylbutanoic acid
• CAS No.: 41785-81-3
• Molecular Formula: C10H20O2
• Molecular Weight: 172.268
• Mol file: 41785-81-3.mol

Synonyms:2-tert-Butyl-3,3-dimethylbutanoic acid;

Chemical Property of 2-tert-butyl-3,3-dimethylbutanoic acid

Chemical Property:

• Vapor Pressure: 0.00592mmHg at 25°C
• Refractive Index: 1.441
• Boiling Point: 252.8 °C at 760 mmHg
• Flash Point: 111.4 °C
• Density: 0.912 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-tert-butyl-3,3-dimethylbutanoic acid

There total 17 articles about 2-tert-butyl-3,3-dimethylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dimethyl-3,3 tertiobutyl-2 butyrate de methyle (10250-50-7) → 2-tert-Butyl-3,3-dimethylbutanoic acid (41785-81-3)

Guidance literature:

With propyllithium; at 0 ℃; for 36h;

DOI:10.1016/0040-4020(81)85010-7

Reference yield: 85.0%

3,3-Dimethyl-2-tert-butyl-1-butanol (81931-81-9) → 2-tert-Butyl-3,3-dimethylbutanoic acid (41785-81-3)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; In acetone; for 4h; Ambient temperature; ultrasound sonication;

DOI:10.1055/s-1989-27323

Reference yield: 80.0%

2-tert-butyl-2-chloro-3,3-dimethylbutanal (106661-47-6) → 2-tert-Butyl-3,3-dimethylbutanoic acid (41785-81-3)

Guidance literature:

2-tert-butyl-2-chloro-3,3-dimethylbutanal; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -70 ℃;

With hydrogenchloride; In tetrahydrofuran; hexane; water; at 20 ℃;

DOI:10.1002/ejoc.201000888

upstream raw materials:

3,3-Dimethyl-2-tert-butyl-1-butanol

2-tert-butyl-3,3-dimethyl-butyryl chloride

dimethyl-3,3 tertiobutyl-2 butyrate de methyle

di-tert-butylketene

Downstream raw materials:

Di-tert.-butyl-essigsaeure-amid

Refernces

• 1、 Knorr, Rudolf. "Acylation mechanisms of DMSO/[D6]DMSO with Di-tert-butylketene and its congeners". scheme or table. p. 6335 - 6342. Retrieved 2011/12/05.
• 2、 Lyashchuk, S. N.,Skrypnik, Yu. G.. "HETEROCUMULENES IN ACYLATION REACTIONS II. REACTIVITY OF ALKYL-SUBSTITUTED KETENES IN SPONTANEOUS HYDROLYSIS REACTIONS". . p. 10 - 17. Retrieved 2007/10/02.