N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamide

Base Information

• Chemical Name: N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamide
• CAS No.: 86847-64-5
• Molecular Formula: C11H14 N2 O2
• Molecular Weight: 206.244
• Hs Code.: 2933399090
• European Community (EC) Number: 625-350-7
• DSSTox Substance ID: DTXSID30353117
• Nikkaji Number: J329.300I
• Mol file: 86847-64-5.mol

Synonyms:86847-64-5;N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamide;N-(3-formylpyridin-2-yl)pivalamide;N-(3-formylpyridin-2-yl)-2,2-dimethylpropanamide;N-(3-Formyl-pyridin-2-yl)-2,2-dimethyl-propionamide;SCHEMBL1375331;DTXSID30353117;ANABHCSYKASRRW-UHFFFAOYSA-N;3-formyl-2-(pivaloylamino)pyridine;CS-M0436;MFCD01830170;AKOS000320285;AB09960;AS-35624;BP-10381;2-(pivaloylamino)-3-pyridinecarboxaldehyde;FT-0629176;N-(3-Formyl-2-pyrdnyl)-2,2-dmethylpropanamde;2-PIVALYLAMINO-PYRIDINE-3-CARBOXYALDEHYDE;n-(-formyl-2-pyridinyl)-2,2-dimethylpropanamide;A841846;AA-516/12432296;n-(3-formyl-2-pyridinyl)-2-,2dimethylpropanamide;J-523006;N-(3-formyl-2-pyridinyl) -2,2-dimethylpropanamide;N-(3-formylpyridin-2-yl)-2,2-dimethylpropionamide;N-(3-formylpyridin-2-yl)-2.2-dimethylpropionamide;N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamide, 97%;N-(3-formyl-2-pyridyl)-2,2-dimethyl-propanamide

Chemical Property of N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamide

Chemical Property:

• Vapor Pressure: 8.35E-07mmHg at 25°C
• Melting Point: 85-88°C
• Boiling Point: 406.1 °C at 760 mmHg
• Flash Point: 199.4 °C
• PSA: 59.06000
• Density: 1.165 g/cm³
• LogP: 1.95170
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 206.105527694
• Heavy Atom Count: 15
• Complexity: 246

Purity/Quality:

96% 1H NMR ^*data from raw suppliers

N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)(C)C(=O)NC1=C(C=CC=N1)C=O
• Uses: Reactant for:Preparation of disubstituted azaindolines Reactant for:? ;Preparation of disubstituted azaindolines1

Technology Process of N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamide

There total 12 articles about N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

2-(pivaloylamino)pyridine (86847-59-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N-(3-formyl-2-pyridinyl)-2,2-dimethylpropanamide (86847-64-5)

Guidance literature:

2-(pivaloylamino)pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - 0 ℃;

Reference yield: 90.0%

2-Aminonicotinaldehyde (7521-41-7) + pivaloyl chloride (3282-30-2) → N-(3-formyl-2-pyridinyl)-2,2-dimethylpropanamide (86847-64-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 63h;

Reference yield: 85.0%

4-morpholinecarboxaldehyde (4394-85-8) → N-(3-formyl-2-pyridinyl)-2,2-dimethylpropanamide (86847-64-5)

Guidance literature:

2-(pivaloylamino)pyridine; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 1.5h;

4-morpholinecarboxaldehyde; In tetrahydrofuran; pentane; at -78 - 20 ℃;

upstream raw materials:

2-(pivaloylamino)pyridine

N,N-dimethyl-formamide

2-aminopyridine

pivaloyl chloride

Downstream raw materials:

(2-amino-3-pyridinyl)methanol

2-methyl-[1,8]naphthyridine

2,7-dimethyl-[1,8]naphthyridine

ethyl 1-benzyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

Refernces

• 1、 Kusuma, Indra,Komuro, Takashi,Tobita, Hiromi. "Diruthenium complexes with a 1,8-Naphthyridine-based Bis(silyl) supporting ligand: Synthesis and structures of complexes containing RuII2(μ-H)2 and RuI2 cores". . p. 400 - 403. Retrieved 2018/03/27.
• 2、 -. "RING-FUSED 2-PYRIDONE DERIVATIVES AND HERBICIDES". Page/Page column 68. . Retrieved 2011/12/12.