3'-Amino-2',3'-dideoxyadenosine

Base Information

• Chemical Name: 3'-Amino-2',3'-dideoxyadenosine
• CAS No.: 7403-25-0
• Molecular Formula: C₁₀H₁₄N₆O₂
• Molecular Weight: 250.26
• Hs Code.: 2934999090
• Mol file: 7403-25-0.mol

Synonyms:3'-Amino-2',3'-dideoxyadenosine;9-(3-Amino-2,3-dideoxy-β-D-erythro-pentofuranosyl)adenine;2',3'-dideoxy-3'-aminoadenosine;

Chemical Property of 3'-Amino-2',3'-dideoxyadenosine

Chemical Property:

• Boiling Point: 571.6 °C at 760 mmHg
• Flash Point: 299.5 °C
• PSA: 125.10000
• Density: 1.91 g/cm³
• LogP: 0.29710

Purity/Quality:

98%,99%, ^*data from raw suppliers

3''-Amino-2'',3''-dideoxyadenosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-Amino-2',3'-dideoxyadenosine

There total 6 articles about 3'-Amino-2',3'-dideoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

adenine (66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9) + 3'-amino-3'-deoxythymidine (52450-18-7) → 9-(3'-amino-2',3'-dideoxy-β-D-ribofuranosyl)adenine (125944-11-8,7403-25-0)

Guidance literature:

With phosphate buffer; glutaraldehyde-treated cells of E_.coli BM-11; Na-acetate buffer; at 50 ℃; for 24h;

DOI:10.1080/15257779408013281

Reference yield:

9-(3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)adenine (66323-44-2) → 9-(3'-amino-2',3'-dideoxy-β-D-ribofuranosyl)adenine (125944-11-8,7403-25-0)

Guidance literature:

With ammonium hydroxide; Polystyryl diphenylphosphine resin; Yield given. Multistep reaction; 1.) dioxane, r.t., 2 h; 2.) dioxane, r.t., 2 h;

DOI:10.1055/s-1994-25575

Reference yield:

3'-azido-2',3'-dideoxy-N6-isobutyryladenosine → 9-(3'-amino-2',3'-dideoxy-β-D-ribofuranosyl)adenine (125944-11-8,7403-25-0)

Guidance literature:

With ammonium hydroxide; Polystyryl diphenylphosphine resin; Yield given. Multistep reaction; 1.) dioxane, r.t., 2 h; 2.) dioxane, r.t., 12 h;

DOI:10.1055/s-1994-25575

upstream raw materials:

9-(3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)adenine

adenine

3'-amino-3'-deoxythymidine

5'-O-trityl-2,3'-anhydrothymidine

Downstream raw materials:

3'-tritylamino-2',3'-dideoxyadenosine

N-benzoyl-2 ^{FontWeight=Bold FontSize=10} ',3'-dideoxy-3'-[(triphenylmethyl)amino]adenosine

3'-N-[N-allyloxycarbonyl-S-(tert-butylthio)-L-cysteinyl]-5'-O-(tert-butyldimethylsilyl)-N6,N6-{2-[3-oxo-3-(pentafluorophenyloxy)propyl]}glutaryl-9-(3'-amino-2',3'-dideoxy-β-D-ribofuranosyl)adenine

3'-azido-2',3'-deoxythymidine

Refernces

• 1、 Zaitseva,Kvasyuk,Vaaks,Barai,Bokut,Zinchenko,Mikhailopulo. "Chemical-enzymatic synthesis of 3'-amino-2',3'-dideoxy-β-D- ribofuranosides of natural heterocyclic bases and their 5'-monophosphates". . p. 819 - 834. Retrieved 2007/10/02.