2,3,6-trihydroxybenzoic acid

Base Information

• Chemical Name: 2,3,6-trihydroxybenzoic acid
• CAS No.: 16534-78-4
• Molecular Formula: C7H6 O5
• Molecular Weight: 170.122
• Mol file: 16534-78-4.mol

Synonyms:2,3,6-Trihydroxybenzoicacid

Chemical Property of 2,3,6-trihydroxybenzoic acid

Chemical Property:

• Vapor Pressure: 2.72E-08mmHg at 25°C
• Boiling Point: 433.7°C at 760 mmHg
• Flash Point: 230.2°C
• Density: 1.749g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,6-trihydroxybenzoic acid

There total 5 articles about 2,3,6-trihydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2,3,6-trimethoxybenzoic acid (60241-74-9) → 2,3,6-trihydroxybenzoic acid (16534-78-4)

Guidance literature:

With boron tribromide; In dichloromethane; at -80 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bbrc.2021.01.042

Reference yield: 13.0%

2,5-dihydroxybenzoic acid. (490-79-9) → 2,3,6-trihydroxybenzoic acid (16534-78-4)

Guidance literature:

With ceric (IV) amonium sulphate; In tetrachloromethane; for 0.75h;

DOI:10.1021/jo00198a035

Reference yield:

2,3-Dihydroxybenzoic acid (303-38-8) → 2,3,6-trihydroxybenzoic acid (16534-78-4)

Guidance literature:

With recombinant 3-hydroxybenzoate 6-hydroxylase from Rhodococcus jostii RHA₁; NADH; at 25 ℃; pH=8; Concentration; pH-value; Reagent/catalyst; regioselective reaction; Kinetics; Tris-SO₄ buffer; Enzymatic reaction;

DOI:10.1016/j.bbapap.2011.12.003

upstream raw materials:

2,5-dihydroxybenzoic acid.

2,3,6-trimethoxybenzoic acid

1,2,4-Trihydroxybenzene

2,3-Dihydroxybenzoic acid

Downstream raw materials:

2,3,6-trimethoxybenzoic acid

2,3,6-trihydroxy-benzoic acid methyl ester

2-Hydroxy-3,6-dioxo-cyclohexa-1,4-dienecarboxylic acid; compound with 2,3,6-trihydroxy-benzoic acid

Refernces

• 1、 Montersino, Stefania,Van Berkel, Willem J.H.. "Functional annotation and characterization of 3-hydroxybenzoate 6-hydroxylase from Rhodococcus jostii RHA1". experimental part. p. 433 - 442. Retrieved 2012/07/14.