2-(3-METHOXYALLYLIDENE)MALONIC ACID DIMETHYL ESTER, 96

Base Information

• Chemical Name: 2-(3-METHOXYALLYLIDENE)MALONIC ACID DIMETHYL ESTER, 96
• CAS No.: 41530-32-9
• Molecular Formula: C9H12 O5
• Molecular Weight: 200.191
• Hs Code.: 2918990090
• Mol file: 41530-32-9.mol

Synonyms:Propanedioicacid, (3-methoxy-2-propenylidene)-, dimethyl ester (9CI); Dimethyl 3-methoxyallylidenemalonate

Chemical Property of 2-(3-METHOXYALLYLIDENE)MALONIC ACID DIMETHYL ESTER, 96

Chemical Property:

• Vapor Pressure: 0.0169mmHg at 25°C
• Refractive Index: 1.5380 (estimate)
• Boiling Point: 254.8°Cat760mmHg
• Flash Point: 105.9°C
• PSA: 61.83000
• Density: 1.128g/cm³
• LogP: 0.41890

Purity/Quality:

99% ^*data from raw suppliers

Dimethyl3-Methoxyallylidenemalonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Dimethyl 3-Methoxyallylidenemalonate is used to prepare pyridinonyl PDK1 inhibitors and pyrrolo[3,2-c]pyridine derivatives as kinase inhibitors for treating cancer.

Technology Process of 2-(3-METHOXYALLYLIDENE)MALONIC ACID DIMETHYL ESTER, 96

There total 2 articles about 2-(3-METHOXYALLYLIDENE)MALONIC ACID DIMETHYL ESTER, 96 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

malonaldehydebis(dimethylacetal) (102-52-3) + malonic acid dimethyl ester (108-59-8) → 1,3-dimethyl 2-(3-methoxyprop-2-en-1-ylidene)propanedioate (41530-32-9)

Guidance literature:

With acetic anhydride; zinc(II) chloride; at 140 ℃; for 1h;

Reference yield:

→ 1,3-dimethyl 2-(3-methoxyprop-2-en-1-ylidene)propanedioate (41530-32-9)

Guidance literature:

1,1,3,3-Tetramethoxypropan, Malonsaeuredimethylester;

Reference yield: 90.0%

1,3-dimethyl 2-(3-methoxyprop-2-en-1-ylidene)propanedioate (41530-32-9) + 3,4-difluorobenzylamine (72235-53-1) → 1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid (1001413-01-9)

Guidance literature:

1,3-dimethyl 2-(3-methoxyprop-2-en-1-ylidene)propanedioate; 3,4-difluorobenzylamine; In iso-butanol; at 5 - 100 ℃;

With water; sodium hydroxide; In methanol; iso-butanol; at 20 ℃; for 2h;

With hydrogenchloride; In methanol; water; iso-butanol;

upstream raw materials:

malonaldehydebis(dimethylacetal)

malonic acid dimethyl ester

Downstream raw materials:

1-(2,6-dimethylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid

N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-1-(2,6-dimethylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Refernces