Artemotil

Base Information Edit

Chemical Name:Artemotil
CAS No.:75887-54-6
Molecular Formula:C17H28O5
Molecular Weight:312.406
Hs Code.:
UNII:XGL7GFB9YI
Nikkaji Number:J362.163D
Wikipedia:Artemotil
Wikidata:Q72443831
NCI Thesaurus Code:C73002
Metabolomics Workbench ID:154629
ChEMBL ID:CHEMBL301267
Mol file:75887-54-6.mol

Synonyms:arteether;arteether, (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,12aR*))-isomer;arteether, (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10beta,12beta,12aR*))-isomer;artemotil;artether;beta-artether;SM-227

Suppliers and Price of Artemotil

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Arteether
25mg
$ 285.00

TRC
Arteether
100mg
$ 970.00

Medical Isotopes, Inc.
Arteether
50 mg
$ 2000.00

Labseeker
Arteether 98
1g
$ 308.00

CSNpharm
Arteether
25mg
$ 125.00

CSNpharm
Arteether
10mg
$ 68.00

CSNpharm
Arteether
1mg
$ 35.00

CSNpharm
Arteether
50mg
$ 238.00

Crysdot
Arteether 98+%
100mg
$ 384.00

Crysdot
Arteether 98+%
50mg
$ 224.00

Total 110 raw suppliers

Chemical Property of Artemotil Edit

Chemical Property:

Appearance/Colour:white crystalline solid
Vapor Pressure:2.06E-05mmHg at 25°C
Melting Point:80-820 °C
Refractive Index:1.516
Boiling Point:372.4 °C at 760 mmHg
Flash Point:146 °C
PSA：46.15000
Density:1.16 g/cm³
LogP:3.23090
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly)
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:312.19367399
Heavy Atom Count:22
Complexity:443

Purity/Quality:

99% ^*data from raw suppliers

Arteether ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1C(C2CCC(C3C24C(O1)OC(CC3)(OO4)C)C)C
Isomeric SMILES:CCO[C@@H]1[C@@H]([C@@H]2CC[C@H]([C@H]3[C@]24[C@H](O1)O[C@@](CC3)(OO4)C)C)C
Description Arteether reached the market in the Netherlands as a solution in sesame oil, administered by i.m. injection, for the treatment of severe malaria infections in children and adolescents. Artheether, a sesquiterpene acetal with an endoperoxide bridge, is an ether derivative of the naturally occuring compound artemisinin, the active component of Chinese herbal remedies. As the other structural analogs of artemisinin, such as artesunate or artemether, it acts rapidly against Plasmodium, the parasite responsible for the disease, during the early blood stage of its development. It also exhibits a gametocytocidal activity against Plasmodium falciparum, reducing its potential for transmission. Because the only controlled clinical studies had been performed in children and adolescents, this new antimalarial drug was only approved for young patients. Further studies in adults treated with 150 mg i.m. artemotil, once daily for three consecutive days, indicated that the drug was efficient, rapidly acting (parasite clearance time meanly 38 h) and well tolerated. A new promising achievement in the regression of malaria is the combination of artemisinin derivatives with other long-lived antimalarials as mefloquine or pyrimethamine/sulfa.
Uses Derivative of Artemisinin. Antimalarial

Technology Process of Artemotil

There total 20 articles about Artemotil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.5%