Technology Process of Faropenem
There total 6 articles about Faropenem which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride; palladium on activated charcoal; hydrogen;
In
methanol;
at 40 ℃;
for 16h;
under 3040.2 Torr;
- Guidance literature:
-
(5R,6S)-6-[1(R)-hydroxyethyl]-2-[2(R)-tetrahydrofuryl]penem-3-carboxylic acid 4-nitrobenzyl ester;
With
hydrogen; sodium hydrogencarbonate;
5%-palladium/activated carbon;
In
water; ethyl acetate;
at 20 - 30 ℃;
under 4413.43 - 5149.01 Torr;
With
hydrogenchloride;
In
water;
for 1h;
pH=1.8 - 2.0;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydroxide / acetone / 2 h / 0 - 20 °C / pH 8 - 10
2: triethylamine / dichloromethane / 2 h / 0 - 5 °C
3: triethyl phosphite / 5,5-dimethyl-1,3-cyclohexadiene / 5 h / Reflux
4: hydrogenchloride; palladium on activated charcoal; hydrogen / methanol / 16 h / 40 °C / 3040.2 Torr
With
hydrogenchloride; palladium on activated charcoal; hydrogen; triethylamine; sodium hydroxide; triethyl phosphite;
In
methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; acetone;
