Tetraisopropyl methylenediphosphonate

Base Information Edit

Chemical Name:Tetraisopropyl methylenediphosphonate
CAS No.:1660-95-3
Molecular Formula:C13H30O6P2
Molecular Weight:344.325
Hs Code.:29319090
European Community (EC) Number:216-765-0
NSC Number:226577
UNII:K46Y5V9U61
DSSTox Substance ID:DTXSID7044847
Nikkaji Number:J195.300A
Wikidata:Q27281937
ChEMBL ID:CHEMBL3183026
Mol file:1660-95-3.mol

Synonyms:Tetraisopropyl methylenediphosphonate;1660-95-3;tetraisopropyl methylenebis(phosphonate);Phosphonic acid, methylenebis-, tetrakis(1-methylethyl) ester;Tetraisopropyl methylenebisphosphonate;Methylenediphosphonic acid tetraisopropyl ester;2-[di(propan-2-yloxy)phosphorylmethyl-propan-2-yloxyphosphoryl]oxypropane;Phosphonic acid, methylenedi-, tetraisopropyl ester;UNII-K46Y5V9U61;DTXSID7044847;C13H30O6P2;K46Y5V9U61;tetra-i-Propylmethylenediphosphonate;EINECS 216-765-0;Phosphonic acid, P,P'-methylenebis-, P,P,P',P'-tetrakis(1-methylethyl) ester;MFCD00015021;NSC-226577;bis(propan-2-yl) {[bis(propan-2-yloxy)phosphoryl]methyl}phosphonate;Tetrakis(1-methylethyl) Methylenediphosphonate;DTXCID5024847;CAS-1660-95-3;Medronic acid impurity B;SCHEMBL114969;CHEMBL3183026;tetraisopropylmethanediphosphonate;2-[diisopropoxyphosphorylmethyl(isopropoxy)phosphoryl]oxypropane;AMY32007;BCP22455;Tox21_113797;Tox21_301267;NSC226577;Phosphonic acid, tetraisopropyl ester;tetraisopropyl methylene diphosphonate;tetraisopropyl(methylene)bisphosphonate;tetraisopropylmethylenebis(phosphonate);AKOS003600014;C13-H30-O6-P2;CS-W011893;NSC 226577;tetraisopropyl methane diphosphonic acid;Methylenebis(phosphonic acid diisopropyl);NCGC00253673-01;NCGC00256259-01;AS-64438;SY043329;tetraisopropyl methane-1,1-bisphosphonate;TETRAISOPROPYLMETHYLENEDIPHOSPHONATE;Tetraisopropyl methylenediphosphonate, 97%;FT-0653196;M1319;D70431;EN300-203931;Phosphonic acid, tetrakis(1-methylethyl) ester;A810693;SR-01000944763;TETRAKIS(O-ISOPROPYL) METHYLENEDIPHOSPHONATE;SR-01000944763-1;W-109690;Q27281937;F8889-7210;Z1954802106;Tetraisopropyl methylenediphosphonate(for Disodium clodronate);((DIISOPROPOXYPHOSPHINYL)METHYL)DIISOPROPOXYPHOSPHINE OXIDE;Phosphonic acid, 1,1-methylenebis-tetrakis(1-methylethyl) ester;Bis(propan-2-yl) {[bis(propan-2-yloxy)-phosphoryl]methyl}phosphonate;Medronic acid impurity B, European Pharmacopoeia (EP) Reference Standard;2-(p-tolylsulfonylamino)propanoic acid

Suppliers and Price of Tetraisopropyl methylenediphosphonate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Tetraisopropyl Methylenediphosphonate
50g
$ 180.00

TCI Chemical
Tetraisopropyl Methylenediphosphonate >97.0%(GC)
25g
$ 91.00

Sigma-Aldrich
Medronic acid impurity B European Pharmacopoeia (EP) Reference Standard
y0001106
$ 190.00

Sigma-Aldrich
Tetraisopropyl methylenediphosphonate 97%
25ml
$ 129.00

Medical Isotopes, Inc.
Tetraisopropyl Methylenediphosphonate
50 g
$ 750.00

Matrix Scientific
Bis(propan-2-yl){[bis(propan-2-yloxy)-phosphoryl]methyl}phosphonate 95%+
25g
$ 205.00

Matrix Scientific
Bis(propan-2-yl){[bis(propan-2-yloxy)-phosphoryl]methyl}phosphonate 95%+
5g
$ 68.00

Frontier Specialty Chemicals
Tetraisopropyl Methylenediphosphonate 98%
5g
$ 29.00

Frontier Specialty Chemicals
Tetraisopropyl Methylenediphosphonate 98%
25g
$ 117.00

Crysdot
Tetraisopropylmethylenebis(phosphonate) 95+%
25g
$ 130.00

Total 81 raw suppliers

Chemical Property of Tetraisopropyl methylenediphosphonate Edit

Chemical Property:

Appearance/Colour:Clear colorless to slightly yellow liquid
Vapor Pressure:3.04E-06mmHg at 25°C
Refractive Index:n20/D 1.431(lit.)
Boiling Point:400 °C at 760 mmHg
Flash Point:209.2 °C
PSA：90.68000
Density:1.081 g/cm³
LogP:5.03010
Storage Temp.:-20°C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
Water Solubility.:Insoluble in water.
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:344.15176267
Heavy Atom Count:21
Complexity:328

Purity/Quality:

99% ^*data from raw suppliers

Tetraisopropyl Methylenediphosphonate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 41
Safety Statements: 26-36-39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)OP(=O)(CP(=O)(OC(C)C)OC(C)C)OC(C)C
Uses Tetraisopropyl Methylenediphosphonate is used in the preparation of E2-bisphosphonate conjugates as potential anti-osteoporosis agents. Also used in the preparation of AZT 5’-Triphosphate compounds which display inhibitory effects on HIV-1 reverse transcrpitase. Tetraisopropyl methylenediphosphonate [T(iPr)MDP] forms a synergistic mixture with hydrogen dicarbollylcobaltate in nitrobenzene which was used in the extraction of europium and americium.It may be used in the synthesis of the following:tetraisopropyl ethenylidenebisphosphonate.tetraisopropyl 4-acetylthiobutane-1,1-diphosphonatetetraisopropyl 2-(3,5-bis(bromomethyl)phenyl)ethane-1,1-diphosphonate

Technology Process of Tetraisopropyl methylenediphosphonate

There total 12 articles about Tetraisopropyl methylenediphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%