2-Ethoxytetrahydrofuran

Base Information

• Chemical Name: 2-Ethoxytetrahydrofuran
• CAS No.: 13436-46-9
• Molecular Formula: C6H12O2
• Molecular Weight: 116.16
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID10928589
• Nikkaji Number: J302.923I
• Mol file: 13436-46-9.mol

Synonyms:2-Ethoxytetrahydrofuran;13436-46-9;2-ethoxyoxolane;Furan, 2-ethoxytetrahydro-;EINECS 236-569-9;SCHEMBL239230;2-Ethoxytetrahydrofuran, 99%;Ethyl tetrahydro-2-furyl ether;(+/-)-2-Ethoxytetrahydrofuran;DTXSID10928589;FURAN,2-ETHOXYTETRAHYDRO-;AKOS015915920;FT-0636892;J-006526

Chemical Property of 2-Ethoxytetrahydrofuran

Chemical Property:

• Vapor Pressure: 0.697mmHg at 25°C
• Refractive Index: n20/D 1.414(lit.)
• Boiling Point: 171 °C at 760 mmHg
• Flash Point: 16.1 °C
• PSA: 18.46000
• Density: 0.94 g/cm³
• LogP: 1.15940
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 116.083729621
• Heavy Atom Count: 8
• Complexity: 63.5

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Ethoxytetrahydrofuran 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F
• Hazard Codes: F
• Statements: 11
• Safety Statements: 16-29-33

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1CCCO1
• Uses: 2-Ethoxytetrahydrofuran was used to investigate quantitative, regioselective, O-acylative cleavage of tetrahydrofurans using organic acid halides in the presence of Bi(III) halides.

Technology Process of 2-Ethoxytetrahydrofuran

There total 9 articles about 2-Ethoxytetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethanol (64-17-5) + 4-hydroxybutyraldehyde (25714-71-0) → 2-ethoxytetrahydrofuran (13436-46-9)

Guidance literature:

With sulfuric acid; In hexane; water; at 22 ℃; for 24h;

DOI:10.1080/00397919308011181

Reference yield: 60.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + ethanol (64-17-5) → 2-ethoxytetrahydrofuran (13436-46-9)

Guidance literature:

With 3-chloroprop-1-ene; for 15h; Reflux;

DOI:10.1016/j.tetlet.2010.09.014

Reference yield: 40.0%

2,3-dihydro-2H-furan (1191-99-7,75454-45-4) + ethanol (64-17-5) → 2-ethoxytetrahydrofuran (13436-46-9)

Guidance literature:

With toluene-4-sulfonic acid; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(97)01063-6

upstream raw materials:

2,3-dihydro-2H-furan

ethanol

2-methoxytetrahydrofuran

ethylmagnesium bromide

Downstream raw materials:

4-Ethoxy-4-phenylselanyl-butan-1-ol

2-(5-methyl-1H-indol-3-yl)ethan-1-ol

5-methoxytryptophol

2-(3-indole)-ethanol

Refernces

• 1、 Troisi, Luigino,Granito, Catia,Ronzini, Ludovico,Rosato, Francesca,Videtta, Valeria. "An economic and efficient tetrahydrofuranylation of alcohols, imines and alkynes". experimental part. p. 5980 - 5983. Retrieved 2010/11/21.
• 2、 Barton, Derek H. R.,Launay, Franck. "The selective functionalization of saturated hydrocarbons. Part 40. Aspects of Fe(II) based peroxide fragmentation in pyridine solution". . p. 14565 - 14578. Retrieved 2007/10/03.