1H-INDENE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 1H-INDENE-3-CARBOXYLIC ACID
• CAS No.: 5020-21-3
• Molecular Formula: C10H8 O2
• Molecular Weight: 160.172
• Hs Code.: 2916399090
• Mol file: 5020-21-3.mol

Synonyms:Indene-1-carboxylicacid (6CI,7CI,8CI)

Chemical Property of 1H-INDENE-3-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.21E-05mmHg at 25°C
• Melting Point: 145-148°C
• Refractive Index: 1.4108 (estimate)
• Boiling Point: 297.6°Cat760mmHg
• PKA: 3.93±0.20(Predicted)
• Flash Point: 135.9°C
• PSA: 37.30000
• Density: 1.312g/cm³
• LogP: 1.71070
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

1H-Indene-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1H-Indene-3-carboxylic Acid is used for preparing esters of 1-Fluorindan-1-carboxylic Acid (FICA) as a chiral derivatizing agent.

Technology Process of 1H-INDENE-3-CARBOXYLIC ACID

There total 2 articles about 1H-INDENE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Hydroxy-inden-1-ylidene-methanol anion (153470-53-2) → 1H-indene-1-carboxylic acid (5020-21-3) + 3H-indene-1-carboxylic acid (14209-41-7)

Guidance literature:

With perchloric acid; at 25 ℃; Rate constant;

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 3-1H-indenyllithium (20669-47-0,132884-21-0) → 1H-indene-1-carboxylic acid (5020-21-3) + 3H-indene-1-carboxylic acid (14209-41-7)

Guidance literature:

DOI:10.1021/ja00326a013

Reference yield: 82.0%

1H-indene-1-carboxylic acid (5020-21-3) → Indan-1-carboxylic acid (14381-42-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 12h;

DOI:10.1246/bcsj.69.3591

upstream raw materials:

carbon dioxide

3-1H-indenyllithium

Hydroxy-inden-1-ylidene-methanol anion

Downstream raw materials:

Indan-1-carboxylic acid

3H-indene-1-carboxylic acid

benzofulvene-8,8-diol

(-)-(R)-1-indanyl(<1,1-2H2>methyl)bromide

Refernces