Aziridine, 2-(bromomethyl)-1-(phenylsulfonyl)-

Base Information

• Chemical Name: Aziridine, 2-(bromomethyl)-1-(phenylsulfonyl)-
• CAS No.: 5120-12-7
• Molecular Formula: C9H10 Br N O2 S
• Molecular Weight: 276.154
• Hs Code.: 2933990090
• Mol file: 5120-12-7.mol

Synonyms:NSC 53750

Chemical Property of Aziridine, 2-(bromomethyl)-1-(phenylsulfonyl)-

Chemical Property:

• Vapor Pressure: 3.4E-06mmHg at 25°C
• Boiling Point: 387°Cat760mmHg
• Flash Point: 187.8°C
• PSA: 45.53000
• Density: 1.665g/cm³
• LogP: 2.47310

Purity/Quality:

1-BENZENESULFONYL-2-BROMOMETHYL-AZIRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Aziridine, 2-(bromomethyl)-1-(phenylsulfonyl)-

There total 11 articles about Aziridine, 2-(bromomethyl)-1-(phenylsulfonyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2,3-dibromopropylamine hydrobromide (6963-32-2) + benzenesulfonyl chloride (98-09-9) → 1-Benzenesulfonyl-2-(bromomethyl)ethylenimine (5120-12-7)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2004.02.059

Reference yield:

N-allylbenzenesulfonamide (50487-70-2) → 1-Benzenesulfonyl-2-(bromomethyl)ethylenimine (5120-12-7)

Guidance literature:

N-allylbenzenesulfonamide; With bromine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

With sodium hydroxide; In ethanol; water; at 20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.3390/molecules24203649

Reference yield:

N-(2,3-dibromo-propyl)-benzenesulfonamide (50487-74-6) → 1-Benzenesulfonyl-2-(bromomethyl)ethylenimine (5120-12-7)

Guidance literature:

With sodium hydroxide; ethanol;

DOI:10.1021/ja01185a057

upstream raw materials:

N-(2,3-dibromo-propyl)-benzenesulfonamide

N-(β,β'-dibromo-isopropyl)-benzenesulfonamide

2,3-dibromopropan-1-amine

benzenesulfonyl chloride

Downstream raw materials:

1,3-Diphenyl-2-benzenesulfonamidopropane

6-benzenesulfonylamino-1-benzyl-4-methylhexahydro-1H-1,4-diazepine

N-(β,β'-dibromo-isopropyl)-benzenesulfonamide

N-(1-ethylpropyl)benzenesulfonamide

Refernces

• 1、 Karikomi, Michinori,D'Hooghe, Matthias,Verniest, Guido,De Kimpe, Norbert. "Regio- and stereocontrolled synthesis of novel 3-sulfonamido-2,3,4,5- tetrahydro-1,5-benzothiazepines from 2-(bromomethyl)- or 2-(sulfonyloxymethyl) aziridines". scheme or table. p. 1902 - 1904. Retrieved 2009/01/31.