5-bromo-N-(3-bromophenyl)-2-hydroxybenzamide

Base Information

• Chemical Name: 5-bromo-N-(3-bromophenyl)-2-hydroxybenzamide
• CAS No.: 24568-50-1
• Molecular Formula: C13H9 Br2 N O2
• Molecular Weight: 371.028
• Mol file: 24568-50-1.mol

Synonyms:Salicylanilide,3',5-dibromo- (7CI,8CI); NSC 526281

Chemical Property of 5-bromo-N-(3-bromophenyl)-2-hydroxybenzamide

Chemical Property:

• Vapor Pressure: 1.63E-06mmHg at 25°C
• Boiling Point: 386.1°C at 760 mmHg
• Flash Point: 187.3°C
• Density: 1.863g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-N-(3-bromophenyl)-2-hydroxybenzamide

There total 2 articles about 5-bromo-N-(3-bromophenyl)-2-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromosalicyclic acid (89-55-4) + m-Bromoaniline (591-19-5) → 5-Brom-salicylsaeure-<3-brom-anilid> (24568-50-1)

Guidance literature:

With phosphorus trichloride; Microwave irradiation;

DOI:10.1016/j.bmc.2013.12.016 DOI:10.1016/j.bioorg.2014.11.005

Reference yield:

→ 5-Brom-salicylsaeure-<3-brom-anilid> (24568-50-1)

Guidance literature:

5-Brom-salisylsaeure u. 3-Brom-anilin in Chlorbenzol m. PCl3 + AlCl3 (Kochen);

DOI:10.1002/jps.2600501006

Reference yield: 74.0%

5-Brom-salicylsaeure-<3-brom-anilid> (24568-50-1) + diethyl chlorophosphate (814-49-3) → 4-bromo-2-[(3-bromophenyl)carbamoyl]phenyl diethyl phosphate (1552270-23-1)

Guidance literature:

5-Brom-salicylsaeure-<3-brom-anilid>; With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h;

diethyl chlorophosphate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2013.12.016

upstream raw materials:

5-bromosalicyclic acid

m-Bromoaniline

Downstream raw materials:

4-bromo-2-[(3-bromophenyl)carbamoyl]phenyl diethyl phosphate

Refernces

• 1、 Krtk, Martin,tpnkov, rka,Vorkov, Katarna,Vinov, Jarmila. "Salicylanilide diethyl phosphates as cholinesterases inhibitors". . p. 48 - 52. Retrieved 2015/02/19.
• 2、 Vinsova, Jarmila,Kratky, Martin,Komloova, Marketa,Dadapeer, Echchukattula,Stipankova, Sarka,Voreakova, Katarina,Stolaoikova, Jioina. "Diethyl 2-(phenylcarbamoyl)phenyl phosphorothioates: Synthesis, antimycobacterial activity and cholinesterase inhibition". . p. 7152 - 7168. Retrieved 2014/07/08.