4-(4-NITROPHENOXY)BENZONITRILE

Base Information

• Chemical Name: 4-(4-NITROPHENOXY)BENZONITRILE
• CAS No.: 17076-68-5
• Molecular Formula: C13H8 N2 O3
• Molecular Weight: 240.218
• Hs Code.: 2926909090
• Mol file: 17076-68-5.mol

Synonyms:Benzonitrile,p-(p-nitrophenoxy)- (7CI,8CI); 4-(4-Nitrophenoxy)benzonitrile;4'-Cyano-4-nitrodiphenyl ether; p-Cyanophenol p-nitrophenyl ether;p-Cyanophenyl p-nitrophenyl ether

Chemical Property of 4-(4-NITROPHENOXY)BENZONITRILE

Chemical Property:

• Vapor Pressure: 2.44E-06mmHg at 25°C
• Boiling Point: 391.6°Cat760mmHg
• Flash Point: 190.6°C
• PSA: 78.84000
• Density: 1.34g/cm³
• LogP: 3.78198
• Storage Temp.: 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

4-(4-Nitrophenoxy)benzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-NITROPHENOXY)BENZONITRILE

There total 19 articles about 4-(4-NITROPHENOXY)BENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-cyanophenol (767-00-0) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 4-(4-nitrophenoxy)benzonitrile (17076-68-5)

Guidance literature:

With cesium fluoride/clinoptilolite; In dimethyl sulfoxide; at 110 ℃; for 0.5h;

DOI:10.1139/cjc-2015-0300

Reference yield: 98.0%

4-cyanophenol (767-00-0) + 4-chlorobenzonitrile (100-00-5) → 4-(4-nitrophenoxy)benzonitrile (17076-68-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 15h; Inert atmosphere;

DOI:10.1039/c6ra08664k

Reference yield: 98.0%

4-cyanophenol (767-00-0) + para-nitrophenyl bromide (586-78-7) → 4-(4-nitrophenoxy)benzonitrile (17076-68-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 15h; Inert atmosphere;

DOI:10.1039/c6ra08664k

upstream raw materials:

4-cyanophenol

4-Fluoronitrobenzene

tert-butyl(4-(1-isocyanovinyl)phenoxy)dimethylsilane

4-(4-nitrophenoxy)aniline

Downstream raw materials:

4-amino-4'-cyanodiphenyl ether

Refernces

• 1、 Sairaman, Anjali,Cardoso, Fernanda Caldas,Bispat, Anjie,Lewis, Richard J.,Duggan, Peter J.,Tuck, Kellie L.. "Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels". supporting information. p. 3046 - 3059. Retrieved 2018/04/06.
• 2、 Keipour, Hoda,Hosseini, Abolfazl,Afsari, Amir,Oladee, Razieh,Khalilzadeh, Mohammad A.,Ollevier, Thierry. "CsF/clinoptilolite: An efficient solid base in SNAr and copper-catalyzed Ullmann reactions". . p. 95 - 104. Retrieved 2016/01/16.