2,4-Dibromo-1-fluorobenzene

Base Information

• Chemical Name: 2,4-Dibromo-1-fluorobenzene
• CAS No.: 1435-53-6
• Molecular Formula: C6H3Br2F
• Molecular Weight: 253.896
• Hs Code.: 29036990
• European Community (EC) Number: 215-860-4
• NSC Number: 88308
• UNII: 8Q9HP36PKV
• DSSTox Substance ID: DTXSID70162447
• Nikkaji Number: J150.115A
• Wikidata: Q72464331
• Mol file: 1435-53-6.mol

Synonyms:2,4-Dibromo-1-fluorobenzene;1435-53-6;1,3-Dibromo-4-fluorobenzene;2,4-DIBROMOFLUOROBENZENE;1-Fluoro-2,4-dibromobenzene;Benzene, 2,4-dibromo-1-fluoro-;C6H3Br2F;8Q9HP36PKV;EINECS 215-860-4;NSC-88308;NSC88308;UNII-8Q9HP36PKV;NCIOpen2_005346;Benzene,4-dibromo-1-fluoro-;SCHEMBL321812;DTXSID70162447;MFCD00000283;NSC 88308;2,4-Dibromo-1-fluorobenzene, 90%;AKOS005762928;AC-9699;CS-W010191;AS-14421;AM20020488;D3489;FT-0609988;EN300-53154;A20536;A20822;2,4-Dibromo-1-fluorobenzene, technical grade, 70%;W-109666;1,3-Dibromo-4-fluorobenzene, tech

Chemical Property of 2,4-Dibromo-1-fluorobenzene

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Vapor Pressure: 0.00261mmHg at 25°C
• Melting Point: 69°C
• Refractive Index: 1.582-1.584
• Boiling Point: 218.4 °C at 760 mmHg
• Flash Point: 82.5 °C
• PSA: 0.00000
• Density: 2.014 g/cm³
• LogP: 3.35070
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: insoluble
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 253.85650
• Heavy Atom Count: 9
• Complexity: 97.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dibromo-1-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Br)Br)F

Technology Process of 2,4-Dibromo-1-fluorobenzene

There total 11 articles about 2,4-Dibromo-1-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-bromo-2-fluoro-benzoic acid (146328-85-0) → 2,4-dibromo-1-fluorobenzene (1435-53-6)

Guidance literature:

With bromine; dibromoisocyanuric acid; In dichloromethane; at 60 ℃; for 24h; Temperature; UV-irradiation;

Reference yield: 70.0%

5-bromo-2-fluoroaniline (2924-09-6) → 2,4-dibromo-1-fluorobenzene (1435-53-6)

Guidance literature:

5-bromo-2-fluoroaniline; With sulfuric acid; sodium nitrite; In water; at 10 ℃;

With hydrogen bromide; copper(I) bromide; at 45 ℃;

Reference yield:

fluorobenzene (462-06-6) → o-fluorobromobenzene (1072-85-1) + 2,4-dibromo-1-fluorobenzene (1435-53-6) + 1-Fluoro-1,2,3,4,5,6-hexabromocyclohexane (359-90-0) + 1-Bromo-4-fluorobenzene (460-00-4)

Guidance literature:

With bromine; In trichlorofluoromethane; for 42h; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts; Irradiation;

DOI:10.1016/S0022-1139(00)82925-5

upstream raw materials:

fluorobenzene

1-Bromo-4-fluorobenzene

bromine

5-bromo-2-fluoro-benzoic acid

Downstream raw materials:

5-bromo-N-(4-methylthiazol-2-yl)-3-phenoxypyridin-2-amine

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF ORGANIC BROMIDES". Paragraph 00139; 00153. . Retrieved 2017/07/28.
• 2、 Bolton, Roger,Owen, Elaine S. E.. "PHOTOCHEMICAL BROMINATION OF ARENES. 2. FLUOROBENZENE DERIVATIVES (1)". . p. 393 - 406. Retrieved 2007/10/02.