3',4'-Dihydroxyflavone

Base Information

• Chemical Name: 3',4'-Dihydroxyflavone
• CAS No.: 4143-64-0
• Molecular Formula: C15H10O4
• Molecular Weight: 254.242
• Hs Code.: 2914501900
• UNII: KOH101S66V
• DSSTox Substance ID: DTXSID70194349
• Nikkaji Number: J354.017K
• Wikidata: Q27282353
• Pharos Ligand ID: R97KU3BT93N4
• Metabolomics Workbench ID: 74493
• ChEMBL ID: CHEMBL222556
• Mol file: 4143-64-0.mol

Synonyms:3',4'-dihydroxy-flavone;3',4'-dihydroxyflavone

Chemical Property of 3',4'-Dihydroxyflavone

Chemical Property:

• Melting Point: 251-253 °C
• Boiling Point: 482.3 °C at 760 mmHg
• PKA: 8.29±0.18(Predicted)
• Flash Point: 188.4 °C
• PSA: 70.67000
• Density: 1.443 g/cm³
• LogP: 2.87120
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 254.05790880
• Heavy Atom Count: 19
• Complexity: 390

Purity/Quality:

98%,99%, ^*data from raw suppliers

3'',4''-Dihydroxyflavone ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=O)C=C(O2)C3=CC(=C(C=C3)O)O

Technology Process of 3',4'-Dihydroxyflavone

There total 17 articles about 3',4'-Dihydroxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-(2-hydroxy-phenyl)-propane-1,3-dione → 3',4'-dihydroxyflavone (4143-64-0)

Guidance literature:

With sulfuric acid; In acetic acid; at 95 - 100 ℃; for 1h;

DOI:10.1021/jo00016a015

Reference yield: 68.0%

3',4'-dimethoxyflavone (4143-62-8) → 3',4'-dihydroxyflavone (4143-64-0)

Guidance literature:

With pyridine hydrochloride; at 140 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmcl.2017.03.057

Reference yield: 62.0%

2-[3,4-di(benzyloxy)phenyl]-4H-chromen-4-one → 3',4'-dihydroxyflavone (4143-64-0)

Guidance literature:

With 10% palladium hydroxide on charcoal; hydrogen; In ethanol; at 60 ℃; for 1h;

DOI:10.3987/COM-13-S(S)107

upstream raw materials:

3',4'-dimethoxyflavone

(E)-2'-hydroxy-3,4-dimethoxychalcone

o-hydroxyacetophenone

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

3,3',4'-trihydroxyflavone

3',4'-dihydroxyflavone-4'-phosphate

Refernces

• 1、 An, Ji-Young,Lee, Hwi-Ho,Shin, Ji-Sun,Yoo, Hyung-Seok,Park, Jong Seon,Son, Seung Hwan,Kim, Sang Won,Yu, Jihyun,Lee, Jun,Lee, Kyung-Tae,Kim, Nam-Jung. "Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cells". . p. 2613 - 2616. Retrieved 2017/05/10.
• 2、 -. "NEUROPROTECTIVE POLYPHENOL ANALOGS". Sheet 14/17. . Retrieved 2013/03/26.