N-(Hydroxymethyl)acetamide

Base Information

• Chemical Name: N-(Hydroxymethyl)acetamide
• CAS No.: 625-51-4
• Molecular Formula: C3H7 N O2
• Molecular Weight: 89.0941
• Hs Code.: 2924199090
• European Community (EC) Number: 210-897-2
• UNII: RCG03A51MO
• DSSTox Substance ID: DTXSID50211543
• Nikkaji Number: J505C
• Wikidata: Q27288052
• Mol file: 625-51-4.mol

Synonyms:N-(Hydroxymethyl)acetamide;625-51-4;Acetamidomethanol;Formicin;N-Hydroxymethylacetamide;Acetamide, N-(hydroxymethyl)-;N-Acetylmethanolamine;MFCD00014417;formaldehyde acetamide;EINECS 210-897-2;UNII-RCG03A51MO;N-(hydroxymethyl)-acetamide;BRN 0506226;RCG03A51MO;4-02-00-00405 (Beilstein Handbook Reference);INDIUMTELLURIDE;FORMICIN [MI];METHYLAL ACETAMIDE;N-hydroxymethyl acetamide;DTXSID50211543;BCP26997;AKOS005206859;FD10622;LS-9717;SB83798;SY047960;A1369;BB 0261905;CS-0061075;FT-0626539;EN300-97672;A15711;N-(Hydroxymethyl)acetamide, >=97.0% (CHN);J-523169;Q27288052

Chemical Property of N-(Hydroxymethyl)acetamide

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 2.41E-05mmHg at 25°C
• Melting Point: 48-52 °C
• Refractive Index: 1.431
• Boiling Point: 321.3 °C at 760 mmHg
• PKA: 13.28±0.10(Predicted)
• Flash Point: 148.1 °C
• PSA: 49.33000
• Density: 1.14
• LogP: -0.53680
• Storage Temp.: Store at 0°C
• Sensitive.: Hygroscopic
• Solubility.: Chloroform (Sparingly, Sonicated), DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: Soluble
• XLogP3: -1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 89.047678466
• Heavy Atom Count: 6
• Complexity: 52.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(Hydroxymethyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NCO
• Uses: Antiseptic, disinfectant especially for surgical instruments. N-(Hydroxymethyl)acetamide (cas# 625-51-4) is used as a catalyst in the method for manufacturing sol-gel silica particles method for manufacturing coating substrate coated with silica particles.

Technology Process of N-(Hydroxymethyl)acetamide

There total 7 articles about N-(Hydroxymethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,7-diacetyl-1,3,5,7-tetraaza-bicyclo[3.3.1]nonane (32516-05-5) → formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-(hydroxymethyl)acetamide (625-51-4)

Guidance literature:

With hydrogenchloride; In water; at 25 ℃; for 0.333333h;

Reference yield:

glycylglycine (556-50-3) → acetamide (60-35-5) + N,N-methylenediacetamide (3852-14-0) + N-(hydroxymethyl)acetamide (625-51-4) + N-acetylglycine (543-24-8)

Guidance literature:

In water; Product distribution; Quantum yield; Mechanism; Irradiation; pH 6; var. dipeptides, other pH and times;

DOI:10.1021/ja00005a053

Reference yield:

acetamide (60-35-5) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → N-(hydroxymethyl)acetamide (625-51-4)

Guidance literature:

With potassium carbonate;

upstream raw materials:

acetamide

formaldehyd

glycylglycine

3,7-diacetyl-1,3,5,7-tetraaza-bicyclo[3.3.1]nonane

Downstream raw materials:

3-acetamidomethyl-6-chloro-2-cyclohexylimidazo<1,2-b>pyridazine

3-acetamidomethyl-2-phenethyl-6-phenylthioimidazo<1,2-b>pyridazine

3-acetamidomethyl-6-benzylthio-2-phenethylimidazo<1,2-b>pyridazine

acetamide

Refernces

• 1、 Albericio, F.,Grandas, A.,Porta, A.,Pedroso, E.,Giralt, E.. "One-Pot Synthesis of S-Acetamidomethyl-N-fluorenylmethoxycarbonyl-L-cysteine (Fmoc-Cys(Acm)-OH)". . p. 271 - 272. Retrieved 1987.
• 2、 Epishina, Margarita A.,Ovchinnikov, Igor V.,Kulikov, Alexander S.,Makhova, Nina N.,Tartakovsky, Vladimir A.. "Henry and Mannich reactions of polynitroalkanes in ionic liquids". scheme or table. p. 21 - 23. Retrieved 2012/04/10.
• 3、 -. "Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents". . . Retrieved 2008/06/13.