N-ACETYLGLYCINAMIDE

Base Information

• Chemical Name: N-ACETYLGLYCINAMIDE
• CAS No.: 2620-63-5
• Molecular Formula: C4H8N2O2
• Molecular Weight: 116.12
• Hs Code.: 2924199090
• European Community (EC) Number: 220-058-2
• NSC Number: 514773
• UNII: 97SV9AFW2Z
• DSSTox Substance ID: DTXSID701031047
• Nikkaji Number: J192.123A
• Wikipedia: N-Acetylglycinamide
• Wikidata: Q6951348
• Mol file: 2620-63-5.mol

Synonyms:Acetamide,2-acetamido- (7CI,8CI);2-Acetamidoacetamide;Aceturamide;N,2'-Biacetamide;N-Acetyl glycine amide;N-Acetylglycinamide;NSC 514773;

Chemical Property of N-ACETYLGLYCINAMIDE

Chemical Property:

• Vapor Pressure: 0.0112mmHg at 25°C
• Melting Point: 140-143 °C(lit.)
• Refractive Index: 1.46
• Boiling Point: 438.1 °C at 760 mmHg
• PKA: 15.58±0.46(Predicted)
• Flash Point: 218.7 °C
• PSA: 72.19000
• Density: 1.146 g/cm³
• LogP: -0.30100
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 116.058577502
• Heavy Atom Count: 8
• Complexity: 111

Purity/Quality:

99% ^*data from raw suppliers

N-Acetylglycinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NCC(=O)N
• Uses: Nα-Acetylglycinamide (2-Acetamidoacetamide) was used in the preparation of 3-unsubstituted 2-pyridones by a tandem reaction with chalcones. N-Acetylglycinamide is a nootropic agent

Technology Process of N-ACETYLGLYCINAMIDE

There total 6 articles about N-ACETYLGLYCINAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-azido-acetamide (1816-91-7) + C2HF3O2*C26H31N2O2P (1290139-20-6) → 2-acetamidoacetamide (2620-63-5)

Guidance literature:

In water-d2; for 30h;

DOI:10.1055/s-0029-1219353

Reference yield: 52.0%

ethyl acetamidoacetate (1906-82-7) → 2-acetamidoacetamide (2620-63-5)

Guidance literature:

With ammonia; In ethanol; for 48h; Ambient temperature;

DOI:10.1007/BF00648899

Reference yield:

ethyl acetamidoacetate (1906-82-7) → 2-acetamidoacetamide (2620-63-5)

Guidance literature:

In ethanol; Yield given;

DOI:10.1039/f19807600915

upstream raw materials:

ethyl acetamidoacetate

2,2-dimethyl-oxazolidin-5-one-imine

acetic anhydride

2-azido-acetamide

Downstream raw materials:

4-(4-methoxyphenyl)-6-phenylpyridin-2(1H)-one

6-(3,4-dimethoxyphenyl)-4-(4-propoxyphenyl)-1H-pyridin-2-one

Refernces

• 1、 Weisbrod, Samuel H.,Marx, Andreas. "Synthesis of water-soluble phosphinophenol for traceless staudinger ligation". experimental part. p. 787 - 789. Retrieved 2010/07/02.
• 2、 Blackburn, G. Michael,Lilley, Terence H.,Walmsley, Elizabeth. "Aqueous Solutions Containing Amino Acids and Peptides. Part 11.-Enthalpy of Dilution of Single and Binary Solute Solutions of N-Acetylglycine Amide, N-Acetyl-L-alanine Amide, N-Acetyl-L-valine Amide and N-Acetyl-L-leucine Amide at 298.15 K". . p. 915 - 922. Retrieved 2007/10/02.