10-hydroxyyohimbine

Base Information

• Chemical Name: 10-hydroxyyohimbine
• CAS No.: 41928-02-3
• Molecular Formula: C21H26N2O4
• Molecular Weight: 370.44
• Mol file: 41928-02-3.mol

Synonyms:10,17α-Dihydroxy-yohimban-16α-carbonsaeure-methylester;10,17α-dihydroxy-yohimban-16α-carboxylic acid methyl ester;(1R,2S,4aR,13bS,14aS)-2,10-Dihydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester;10-hydroxyyohimbine;

Chemical Property of 10-hydroxyyohimbine

Chemical Property:

• Vapor Pressure: 8.12E-15mmHg at 25°C
• Boiling Point: 591.1°C at 760 mmHg
• PKA: 10.31±0.60(Predicted)
• Flash Point: 311.3°C
• PSA: 85.79000
• Density: 1.39g/cm³
• LogP: 2.29060

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 10-hydroxyyohimbine

There total 4 articles about 10-hydroxyyohimbine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

yohimbine (65-19-0) → 10-Hydroxyyohimbine (41928-02-3) + 11-hydroxy-yohimbine (140405-13-6) + 9-Hydroxyyohimbine + 12-Hydroxyyohimbine

Guidance literature:

With sodium persulfate; hydrogen fluoride; antimony pentafluoride; at -35 ℃; for 1h;

DOI:10.1021/np000425z

Reference yield:

→ 10-Hydroxy-3-epi-apo-yohimbin (1360-57-2,37134-57-9,41928-02-3,113951-39-6,114029-62-8,114029-63-9)

Guidance literature:

3-epi-apo-Yohimbin, Cunninghamella blakesleana-Kulturen (bioch. Oxydation);neben 18-Hydroxy-3-epi-apo-yohimbin;

Reference yield:

→ 10-Hydroxy-yohombin (1360-57-2,37134-57-9,41928-02-3,113951-39-6,114029-62-8,114029-63-9)

Guidance literature:

aus Yohimbin durch Hydroxylierung mit 'Cunninghamella Blakesleeana' Lendner;

upstream raw materials:

yohimbine

Refernces

• 1、 Bellet,Truong-Van-Thuong. "Microbiologic hydroxylation of indolic alkaloids". . p. 119 - 122. Retrieved 2007/10/04.