4,4,4-trichlorobutanenitrile

Base Information

• Chemical Name: 4,4,4-trichlorobutanenitrile
• CAS No.: 19376-56-8
• Molecular Formula: C4H4Cl3N
• Molecular Weight: 172.441
• Mol file: 19376-56-8.mol

Synonyms:

Chemical Property of 4,4,4-trichlorobutanenitrile

Chemical Property:

• Vapor Pressure: 0.041mmHg at 25°C
• Boiling Point: 239°C at 760 mmHg
• Flash Point: 101.5°C
• Density: 1.411g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4,4-trichlorobutanenitrile

There total 7 articles about 4,4,4-trichlorobutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

chloroform (67-66-3,8013-54-5) + acrylonitrile (107-13-1,25014-41-9) → 4,4,4-trichloro-butyronitrile (19376-56-8)

Guidance literature:

With potassium hydroxide; tert-butylammonium hexafluorophosphate(V); In benzene; at 5 ℃; for 5h;

DOI:10.1002/ejoc.200701034

Reference yield: 34.0%

chloroform (67-66-3,8013-54-5) + acrylonitrile (107-13-1,25014-41-9) → 4,4,4-trichloro-butyronitrile (19376-56-8) + 1a-methyl-1,1-dichloro-7-cyano-1a,7,7a,7b-tetrahydrocyclopropaindolizin-5(6H)-one (129247-06-9,129312-21-6) + 1a-methyl-1,1-dichloro-7-cyano-1a,7,7a,7b-tetrahydrocyclopropaindolizin-5(6H)-one (129247-06-9,129312-21-6)

Guidance literature:

With picoline; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; at 20 ℃; for 7.5h; Yields of byproduct given;

DOI:10.1007/BF00472551

Reference yield: 17.0%

→ 4,4,4-trichloro-butyronitrile (19376-56-8)

Guidance literature:

upstream raw materials:

chloroform

acrylonitrile

oxirane

ω,ω,ω-trichlorobutanoic acid

Downstream raw materials:

succinic acid

ω,ω,ω-trichlorobutanoic acid

3,3-diphenylpropionitrile

Refernces

• 1、 -. "Catalysts based on vanadium, their preparation and use in the (co)polymerization of alpha-olefins.". . . Retrieved 2008/06/13.
• 2、 Khlebnikov, A. F.,Kostik, E. I.,Kostikov, R. R.,Bespalov, V. Ya.. "1,3-DIPOLAR CYCLOADDITION REACTIONS OF YLIDES FORMED FROM PYRIDINES AND DICHLOROCARBENE". . p. 304 - 311. Retrieved 2007/10/02.