AIDS125547

Base Information

• Chemical Name: AIDS125547
• CAS No.: 13373-11-0
• Molecular Formula: C8H5ClN2S
• Molecular Weight: 196.66
• Hs Code.: 2934999090
• Mol file: 13373-11-0.mol

Synonyms:2-Chlor-5-phenyl-<1,3,4>thiadiazol;2-Phenyl-5-chlor-1,3,4-thiadiazol;2-amino-5-fenil-1,3,4-tiadiazolo;2-chloro-5-phenyl-[1,3,4]thiadiazole;2-Chloro-5-phenyl-1,3,4-thiadiazol;

Chemical Property of AIDS125547

Chemical Property:

• Vapor Pressure: 0.00034mmHg at 25°C
• Melting Point: 88 °C
• Boiling Point: 329.5°C at 760 mmHg
• PKA: -1.88±0.10(Predicted)
• Flash Point: 153.1°C
• PSA: 54.02000
• Density: 1.379g/cm³
• LogP: 2.85850

Purity/Quality:

98%min ^*data from raw suppliers

2-chloro-5-phenyl-1,3,4-thiadiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AIDS125547

There total 13 articles about AIDS125547 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-amino-5-phenyl-1,3,4-thiadiazole (2002-03-1) → 2-chloro-5-phenyl-[1,3,4]thiadiazole (13373-11-0)

Guidance literature:

With hydrogenchloride; copper; sodium nitrite; at -5 - 65 ℃;

DOI:10.1016/j.bmcl.2004.10.007

Reference yield: 56.0%

2-amino-5-phenyl-1,3,4-thiadiazole sulfate (312619-47-9,340169-03-1) → 2-chloro-5-phenyl-[1,3,4]thiadiazole (13373-11-0)

Guidance literature:

2-amino-5-phenyl-1,3,4-thiadiazole sulfate; With hydrogenchloride; sodium nitrite; In water; at 0 - 50 ℃; for 15.1667h;

With sodium hydroxide; In water;

Reference yield:

1-benzylidene thiosemicarbazide (1627-73-2) → 2-chloro-5-phenyl-[1,3,4]thiadiazole (13373-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₄Fe(SO₄)2*12H₂O

2: NaNO₂; aq. HCl / Cu

With hydrogenchloride; ammonium ferric sulfate; sodium nitrite; copper;

DOI:10.1211/146080800128735430

upstream raw materials:

2-amino-5-phenyl-1,3,4-thiadiazole

benzoic acid

1-benzylidene thiosemicarbazide

benzaldehyde

Downstream raw materials:

5-phenyl-1,3,4-thiadiazole-2-thiol

2-ethoxycarbonylmethyl-5-phenyl-1,3,4-thiadiazole

4-(5-phenyl-1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane

N-(2,2,2-trifluoroethyl)-N-methyl-5-phenyl-1,3,4-thiadiazol-2-yl-oxyacetic acid amide

Refernces

• 1、 Barbosa, Juliana M. C.,Bernardino, Patrícia,Decoté-Ricardo, Débora,Fraga, Carlos A. M.,Freitas, Rosana H. C. N.,Melo, Tatiana G.,Salom?o, Kelly,Sueth-Santiago, Vitor,Wardell, James L.,Wardell, Solange M. S. V.,da Silva, Edson F.. "Synthesis and trypanocidal activity of novel pyridinyl-1,3,4-thiadiazole derivatives". . . Retrieved 2020/05/13.
• 2、 Sarkandi, Diba Nabardi,Firoozpour, Loghman,Asadipour, Ali,Sheibani, Vahid,Asli, Mahsa Alizadeh Monavar,Davood, Asghar,Shafiee, Abbas,Foroumadi, Alireza. "Synthesis of 1-Benzyl-4-[2-(5-phenyl-1,3,4-thiadiazole-2-yl)aminoethyl] piperidine as potential alzheimer's disease modifying agent". experimental part. p. 2503 - 2505. Retrieved 2012/01/04.