Diazomethane

Base Information Edit

Chemical Name:Diazomethane
CAS No.:334-88-3
Deprecated CAS:16835-99-7,463-60-5,62024-16-2
Molecular Formula:CH₂N₂
Molecular Weight:42.0403
Hs Code.:
European Community (EC) Number:206-382-7
ICSC Number:1256
UN Number:1953
UNII:60A625P70P
DSSTox Substance ID:DTXSID0024008
Nikkaji Number:J625.947B,J2.576C
Wikipedia:Diazomethane
Wikidata:Q413683
Mol file:334-88-3.mol

Synonyms:Azimethylene;Diazirine; Diazomethane; Diazonium methylide

Suppliers and Price of Diazomethane

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
DIAZOMETHANE 95.00%
5MG
$ 504.83

Total 33 raw suppliers

Chemical Property of Diazomethane Edit

Chemical Property:

Appearance/Colour:white to light yellow crystal powde
Vapor Pressure:2277.092mmHg at 25°C
Melting Point:-145°
Refractive Index:1.4180 (estimate)
Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：37.39000
Density:g/cm³
LogP:-0.00214
XLogP3:1.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:42.021798072
Heavy Atom Count:3
Complexity:25.8
Transport DOT Label:Poison Gas Flammable Gas

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

DIAZOMETHANE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Severe explosion risk when shocked; may explode on contact with alkali metals, rough surfaces, or heat (100C); toxic by inhalation, a carcinogen (OSHA). TLV: 0.2 ppm.
Hazard Codes:T
Statements: 45
Safety Statements: 53-45

MSDS Files:: SDS file from LookChem

Useful:

Chemical Classes:Nitrogen Compounds -> Other Nitrogen Compounds
Canonical SMILES:C=[N+]=[N-]
Inhalation Risk:A harmful concentration of this gas in the air will be reached very quickly on loss of containment.
Effects of Short Term Exposure:The substance is very corrosive to the eyes, skin and respiratory tract. Inhalation of the vapour may cause lung oedema. Inhalation of the vapour may cause asthma-like reactions (RADS). The liquid may cause frostbite. Exposure above the OEL could cause death. Medical observation is indicated.
Effects of Long Term Exposure:Repeated or prolonged inhalation may cause asthma. This substance is possibly carcinogenic to humans.
Description At room temperature, diazomethane (CH2N2) is a toxic yellow gas which can cause significant irritation upon inhalation. Solutions that contain concentrated diazomethane are highly toxic, and they can result in explosions. When heated, Diazomethane emits toxic fumes made of nitrogen oxides; the toxic fumes are also independent of its decomposition. Diazomethane is used after its preparation in ether or in ether that contains traces of ethanol. It is rarely prepared and applied to other solvents which may include dichloromethane. Diazomethane is related to hydrogen cyanide and formaldehyde in its annotation.
Uses It is used as a methylating agent especially for acidic compounds which may include enols, phenols, and carboxylic acids. Powerful methylating agent for acidic Compounds such as carboxylic acids, phenols, enols. For syntheses with diazomethane see the reviews by Smith, Chem. Rev. 23, 193 (1938); Eistert, Z. Angew. Chem. 54, 99, 124 (1941) translated by Spangler in Newer Methods of Preparative Organic Chemistry (New York, 1948) p 513; J. S. Pizey, Synthetic Reagents vol. 2 (John Wiley, New York, 1974) pp 65-142. It is used in organic synthesis as a methylating agent to methylate acidic compoundssuch as carboxylic acids and phenols. Itis used in trace environmental analysis tomethylate chlorophenoxy acid herbicides. Powerful methylating agent for acidic compounds such as carboxylic acids, phenols, enols; not manufactured for sale and distribution because of toxicity and explosivity

Technology Process of Diazomethane

There total 18 articles about Diazomethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.7%

: 16339-21-2
N-nitroso-β-methylaminoisobutyl methyl ketone

: 186581-53-3,908094-01-9,334-88-3
diazomethane

Guidance literature:: With tetrabutylammomium bromide; potassium hydroxide; In water; at 10 ℃; Temperature; Concentration; Activation energy; Inert atmosphere;