N-Methyl-N-phenylbenzamide

Base Information

• Chemical Name: N-Methyl-N-phenylbenzamide
• CAS No.: 1934-92-5
• Molecular Formula: C14H13 N O
• Molecular Weight: 211.263
• Hs Code.: 2924299090
• European Community (EC) Number: 217-704-0
• NSC Number: 42895
• DSSTox Substance ID: DTXSID70172940
• Nikkaji Number: J199.752A
• Wikidata: Q83043017
• Mol file: 1934-92-5.mol

Synonyms:N-Methyl-N-phenylbenzamide;N-METHYLBENZANILIDE;1934-92-5;Benzanilide, N-methyl-;Benzamide,N-methyl-N-phenyl-;Benzamide, N-methyl-N-phenyl-;EINECS 217-704-0;MFCD00093294;NSC42895;N-Methylbenzoylaniline;N-Methyl-N-benzoylaniline;N-Phenyl-N-methylbenzamide;TimTec1_003148;SCHEMBL493114;DTXSID70172940;HMS1542P02;BAA93492;NSC 42895;NSC-42895;AKOS002984841;AS-57105;SY037939;CS-0151264;Y14677;AE-848/01044026;BRD-K97196990-001-01-5

Chemical Property of N-Methyl-N-phenylbenzamide

Chemical Property:

• Vapor Pressure: 8.12E-05mmHg at 25°C
• Melting Point: 57.5-59 °C
• Boiling Point: 341.3°Cat760mmHg
• PKA: 0.41±0.50(Predicted)
• Flash Point: 154.4°C
• PSA: 20.31000
• Density: 1.13g/cm³
• LogP: 2.96320
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 211.099714038
• Heavy Atom Count: 16
• Complexity: 227

Purity/Quality:

99% ^*data from raw suppliers

N-METHYLBENZANILIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C1=CC=CC=C1)C(=O)C2=CC=CC=C2

Technology Process of N-Methyl-N-phenylbenzamide

There total 133 articles about N-Methyl-N-phenylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trimethyl phosphite (512-56-1) + N-phenyl benzoyl amide (93-98-1,5705-51-1) → N-methyl-N-phenyl-benzamide (1934-92-5)

Guidance literature:

With cyclopentyl methyl ether; sodium hydroxide; at 115 ℃; for 24h; Reagent/catalyst; Inert atmosphere;

DOI:10.1055/s-0036-1591494

Reference yield: 98.0%

benzaldehyde (100-52-7) + N,N-dimethyl-aniline (121-69-7,77733-26-7) → N-methyl-N-phenyl-benzamide (1934-92-5)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In water; ethyl acetate; at 90 ℃; for 24h; Reagent/catalyst; Solvent;

DOI:10.1016/j.tetlet.2013.09.018

Reference yield: 94.5%

N-methyl-N-phenyl-2-nitrobenzenesulfenanilide (33224-04-3) + S-(2-nitrophenyl)benzenecarbothiolate (24197-72-6) → bis(2-nitrophenyl)disulfide (1155-00-6) + N-methyl-N-phenyl-benzamide (1934-92-5)

Guidance literature:

With triphenylphosphine; at 18 - 20 ℃;

upstream raw materials:

N-phenyl benzoyl amide

E-[2-methoxy-1-phenyl-methylene]-phenylamine

benzoyl chloride

N,N-dimethyl-aniline

Downstream raw materials:

benzoic acid ethyl ester

4-(Dimethylamino)benzophenone

N-methylaniline

benzyl alcohol

Refernces

• 1、 Lewis, Frederick D.,Long, Timothy M.. "Anomalous dual fluorescence of benzanilide". . p. 5327 - 5332. Retrieved 1998.
• 2、 Cicco, Luciana,Hernández-Fernández, Jose A.,Salomone, Antonio,Vitale, Paola,Ramos-Martín, Marina,González-Sabín, Javier,Presa Soto, Alejandro,Perna, Filippo M.,Capriati, Vito,García-álvarez, Joaquín. "Copper-catalyzed Goldberg-type C-N coupling in deep eutectic solvents (DESs) and water under aerobic conditions". supporting information. p. 1773 - 1779. Retrieved 2021/03/14.
• 3、 Chen, Changpeng,Ling, Liang,Luo, Meiming,Zeng, Xiaoming. "Chromium-catalyzed ligand-free amidation of esters with anilines". supporting information. p. 762 - 766. Retrieved 2021/04/14.