atpenin A5

Base Information

• Chemical Name: atpenin A5
• CAS No.: 119509-24-9
• Molecular Formula: C15H21 Cl2 N O5
• Molecular Weight: 366.24
• Mol file: 119509-24-9.mol

Synonyms:2(1H)-Pyridinone,3-(5,6-dichloro-2,4-dimethyl-1-oxohexyl)-4-hydroxy-5,6-dimethoxy-,[2S-(2R*,4R*,5S*)]-; Antibiotic FO 125A5; Atpenin A 5; FO 125A5

Chemical Property of atpenin A5

Chemical Property:

• Vapor Pressure: 1.45E-13mmHg at 25°C
• Melting Point: 83-85℃
• Boiling Point: 532.6°C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 275.9°C
• PSA: 88.62000
• Density: 1.31g/cm³
• LogP: 2.78890
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chlroform (Slightly), Ethanol (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

99.3% ^*data from raw suppliers

Atpenin A5 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Enantioselective total synthesis of atpenin A5, a potent mitochondrial complex II (succinate-ubiquinone oxidoreductase) inhibitor, has been achieved by a convergent approach through a coupling reaction between 5-iodo-2,3,4,6-tetraalkoxypyridine and a side-chain aldehyde. The two key segments were synthesized through ortho-metalation/boronation with (MeO)3B/oxidation with mCPBA, ortho-iodination, halogen dance reaction, Sharpless epoxidation and regioselective epoxide-opening reaction.
• Uses: Atpenin A5 is a mitochondrial complex II inhibitor able to protect against cardiac-reperfusion.