Tris(4-methoxyphenyl)methanol

Base Information

• Chemical Name: Tris(4-methoxyphenyl)methanol
• CAS No.: 3010-81-9
• Molecular Formula: C22H22 O4
• Molecular Weight: 350.414
• Hs Code.: 29094990
• European Community (EC) Number: 221-139-5
• UNII: V6E2SNJ8K7
• DSSTox Substance ID: DTXSID10184188
• Nikkaji Number: J205.310A
• Wikidata: Q83055068
• Mol file: 3010-81-9.mol

Synonyms:Tris(4-methoxyphenyl)methanol;3010-81-9;4,4',4''-Trimethoxytrityl alcohol;Methanol, tris(p-methoxyphenyl)-;EINECS 221-139-5;Benzenemethanol, 4-methoxy-.alpha.,.alpha.-bis(4-methoxyphenyl)-;4,4',4''-Trimethoxytriphenylmethanol;Tris(p-methoxyphenyl)methanol;V6E2SNJ8K7;SCHEMBL812742;Tris(4-methoxyphenyl)methanol #;DTXSID10184188;4,4',4"-Trimethoxytrityl alcohol;AMY28796;MFCD00014898;AKOS016003092;AS-60023;CS-0020962;FT-0616979;AMINO-BENZO[1,3]DIOXOL-4-YL-ACETICACID;A820201;4-Methoxy-alpha,alpha-bis(4-methoxyphenyl)benzenemethanol;Benzenemethanol, 4-methoxy-alpha,alpha-bis(4-methoxyphenyl)-

Chemical Property of Tris(4-methoxyphenyl)methanol

Chemical Property:

• Melting Point: 76-77°C
• Boiling Point: 522.1°Cat760mmHg
• PKA: 12.94±0.29(Predicted)
• Flash Point: 269.6°C
• PSA: 47.92000
• Density: 1.159g/cm³
• LogP: 3.99660
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 350.15180918
• Heavy Atom Count: 26
• Complexity: 343

Purity/Quality:

99% ^*data from raw suppliers

Tris(4-methoxyphenyl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)O

Technology Process of Tris(4-methoxyphenyl)methanol

There total 43 articles about Tris(4-methoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

bis(p-methoxyphenyl)methanone (90-96-0) + 4-methoxyphenyl magnesium bromide (13139-86-1) → tris(4-methoxyphenyl)methanol (3010-81-9)

Guidance literature:

4-methoxyphenyl magnesium bromide; With magnesium; ethylene dibromide; In tetrahydrofuran; at 36 - 60 ℃; Schlenk technique; Inert atmosphere;

bis(p-methoxyphenyl)methanone; In tetrahydrofuran; at 0 - 25 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.chempr.2021.02.029

Reference yield: 90.0%

1-bromo-4-methoxy-benzene (104-92-7) + carbonic acid dimethyl ester (616-38-6) → tris(4-methoxyphenyl)methanol (3010-81-9)

Guidance literature:

1-bromo-4-methoxy-benzene; With magnesium; In tetrahydrofuran; for 1h; Inert atmosphere; Reflux;

carbonic acid dimethyl ester; In tetrahydrofuran; for 4h; Inert atmosphere; Reflux;

With water; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.03.104

Reference yield: 89.0%

tetrakis-(4-methoxy-phenyl)-ethanone (19920-04-8) → tris(4-methoxyphenyl)methanol (3010-81-9) + 1,1,2,2-tetrakis(4-methoxyphenyl)ethene (10019-24-6) + 4-methoxybenzoic acid (100-09-4)

Guidance literature:

With trifluoroacetic acid; dibenzoyl peroxide; In 1,2-dichloro-ethane; at 25 ℃; for 24h; in a sealed tube;

upstream raw materials:

tris(4-methoxyphenyl)methane

ethyl 4-methoxybenzoate

4-methoxyphenyl magnesium bromide

4,4',4''-trimethoxytrityl chloride

Downstream raw materials:

tris(4-methoxyphenyl)methane

4,4',4''-trimethoxytrityl chloride

1,1,1-tris(4-methoxyphenyl)ethane

C₂₂H₂₁O₃⁽¹⁺⁾

Refernces

• 1、 Guieu, Samuel,Rocha, Jo?o,Silva, Artur M.S.. "Synthesis, crystal structure, and luminescence of tetrakis(4-methoxyphenyl) methane". . p. 2870 - 2873. Retrieved 2013.
• 2、 Lutz, Marius D.R.,Gasser, Valentina C.M.,Morandi, Bill. "Shuttle arylation by Rh(I) catalyzed reversible carbon–carbon bond activation of unstrained alcohols". supporting information. p. 1108 - 1119. Retrieved 2021/04/19.
• 3、 Yadav, Vishal,Rodriguez, Rodolfo J.,Siegler, Maxime A.,Goldberg, David P.. "Determining the Inherent Selectivity for Carbon Radical Hydroxylation versus Halogenation with FeIII(OH)(X) Complexes: Relevance to the Rebound Step in Non-heme Iron Halogenases". supporting information. p. 7259 - 7264. Retrieved 2020/04/22.