10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione

Base Information

• Chemical Name: 10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione
• CAS No.: 897-06-3
• Molecular Formula: C19H24O2
• Molecular Weight: 284.398
• Hs Code.: 29372900
• NSC Number: 49080
• Wikidata: Q105157484
• ChEMBL ID: CHEMBL8512
• Mol file: 897-06-3.mol

Synonyms:NSC-49080;Androsta-1,17-dione;Androstra-1,17-dione;.DELTA.1,17-dione;10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione;CHEMBL8512;1,4-Androsten-3,17-dione;BDBM9954;SCHEMBL3758714;CHEBI:182567;NSC49080;CCG-52094;AKOS015962216;AC-16146;SR-01000641347;SR-01000641347-1;SR-01000641347-2;2,15-dimethyltetracyclo[8.7.0.0;{2,7}.0;{11,15}]heptadeca-3,6-diene-5,14-dione

Chemical Property of 10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 9.62E-08mmHg at 25°C
• Melting Point: 138-139 °C(lit.)
• Refractive Index: 1.568
• Boiling Point: 434.2 °C at 760 mmHg
• Flash Point: 162.1 °C
• PSA: 34.14000
• Density: 1.14 g/cm³
• LogP: 3.86340
• Storage Temp.: Refrigerator
• Water Solubility.: 430mg/L at 20℃
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 284.177630004
• Heavy Atom Count: 21
• Complexity: 584

Purity/Quality:

99% ^*data from raw suppliers

Exemestane Related Compound C United States Pharmacopeia (USP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC12CCC3C(C1CCC2=O)CCC4=CC(=O)C=CC34C
• Description: Androsta-1,4-diene-3,17-dione (Item No. 24081) is an analytical reference standard categorized as an anabolic androgenic steroid. Androsta-1,4-diene-3,17-dione is a precursor in the synthesis of boldenone and has been used to enhance athletic performance. Androsta-1,4-diene-3,17-dione is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.
• Uses: Boldenone related steroid; anabolic androgenic steroid

Technology Process of 10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione

There total 55 articles about 10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-phenylseleno-4-androstene-3,17-dione → Androsta-1,4-diene-3,17-dione (897-06-3)

Guidance literature:

With dihydrogen peroxide; In dichloromethane; for 4h;

DOI:10.1016/j.steroids.2015.02.011

Reference yield: 90.0%

2α-phenylseleno-4-androstene-3,17-dione → Androsta-1,4-diene-3,17-dione (897-06-3)

Guidance literature:

With dihydrogen peroxide; In dichloromethane;

DOI:10.1039/c8nj00063h

Reference yield: 84.0%

androstanedione (846-46-8) → Androsta-1,4-diene-3,17-dione (897-06-3) + 5α-androst-1-ene-3,17-dione (571-40-4)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In fluorobenzene; dimethyl sulfoxide; at 70 ℃; for 24h;

DOI:10.1021/ja012127+

upstream raw materials:

pyridine

5α-androstan-2α,4α-dibromo-3,17-dione

2,4,6-trimethyl-pyridine

progesterone

Downstream raw materials:

Estrone

1-hydroxy-4-methyl-estra-1,3,5⁽¹⁰⁾-trien-17-one

androsta-1,4-diene-3α/β,17β-diol

1-methylestrone

Refernces

• 1、 Brodie et al.. "". . p. 3766. Retrieved 1962.
• 2、 Fan, Ning-Juan,Tang, Jiang-Jiang,Li, Yuan-Feng,Bai, Yu-Bin,Zhao, Xiao-Min. "Synthesis of steroidal [1,2,4]triazolo[1,5-a]pyrimidines and their antiproliferative activities". . p. 822 - 831. Retrieved 2019/08/01.
• 3、 Lone, Shabir H.,Bhat, Muzzaffar A.,Lone, Rayees A.,Jameel, Salman,Lone, Javeed A.,Bhat, Khursheed A.. "Hemisynthesis, computational and molecular docking studies of novel nitrogen containing steroidal aromatase inhibitors: Testolactam and testololactam". . p. 4579 - 4589. Retrieved 2018/03/21.